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001     18246
005     20250129092415.0
024 7 _ |a pmid:21331396
|2 pmid
024 7 _ |a 10.1039/c0an01048k
|2 DOI
024 7 _ |a WOS:000288864000004
|2 WOS
024 7 _ |a 2128/7362
|2 Handle
037 _ _ |a PreJuSER-18246
041 _ _ |a eng
082 _ _ |a 540
084 _ _ |2 WoS
|a Chemistry, Analytical
100 1 _ |a Glöggler, S.
|b 0
|0 P:(DE-HGF)0
245 _ _ |a Selective drug trace detection with low-field NMR
260 _ _ |a Cambridge
|b Soc.
|c 2011
300 _ _ |a 1566 - 1568
336 7 _ |a Journal Article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |a Analyst
|x 0003-2654
|0 8763
|y 8
|v 136
500 _ _ |3 POF3_Assignment on 2016-02-29
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a Advances with para-hydrogen induced polarization open up new fields of applications for portable low-field NMR. Here we report the possibility of tracing drugs down to the micromolar regime. We could selectively polarize nicotine quantities similar to those found in one cigarette. Also less than 1 mg of harmine, a drug used for treatment of Parkinson's disease, and morphine extracted from an opium solution were detectable after polarization with para-hydrogen in single-scan (1)H-experiments. Moreover, we demonstrate the possibility to selectively enhance and detect the (1)H-signal of drug molecules with PHIP in proton rich standard solutions that would otherwise mask the (1)H NMR signal of the drug.
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Drug Residues: analysis
650 _ 2 |2 MeSH
|a Harmine: analysis
650 _ 2 |2 MeSH
|a Hydrogen: chemistry
650 _ 2 |2 MeSH
|a Magnetic Resonance Spectroscopy: methods
650 _ 2 |2 MeSH
|a Morphine: analysis
650 _ 2 |2 MeSH
|a Nicotine: analysis
650 _ 2 |2 MeSH
|a Opium: chemistry
650 _ 2 |2 MeSH
|a Tobacco: chemistry
650 _ 7 |0 1333-74-0
|2 NLM Chemicals
|a Hydrogen
650 _ 7 |0 442-51-3
|2 NLM Chemicals
|a Harmine
650 _ 7 |0 54-11-5
|2 NLM Chemicals
|a Nicotine
650 _ 7 |0 57-27-2
|2 NLM Chemicals
|a Morphine
650 _ 7 |0 8008-60-4
|2 NLM Chemicals
|a Opium
650 _ 7 |a J
|2 WoSType
700 1 _ |a Emondts, M.
|b 1
|u FZJ
|0 P:(DE-Juel1)VDB103106
700 1 _ |a Colell, J.
|b 2
|u FZJ
|0 P:(DE-Juel1)VDB103107
700 1 _ |a Mueller, R.
|b 3
|u FZJ
|0 P:(DE-Juel1)VDB1099
700 1 _ |a Blümich, B.
|b 4
|0 P:(DE-HGF)0
700 1 _ |a Appelt, S.
|b 5
|u FZJ
|0 P:(DE-Juel1)133861
773 _ _ |a 10.1039/c0an01048k
|g Vol. 136, p. 1566 - 1568
|p 1566 - 1568
|q 136<1566 - 1568
|0 PERI:(DE-600)1472713-4
|t The @analyst
|v 136
|y 2011
|x 0003-2654
856 7 _ |u http://dx.doi.org/10.1039/c0an01048k
856 4 _ |u https://juser.fz-juelich.de/record/18246/files/FZJ-18246.pdf
|y Published under German "Allianz" Licensing conditions on 2011-02-17. Available in OpenAccess from 2012-02-17
|z Published final document.
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914 1 _ |y 2011
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