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@ARTICLE{Johnson:183567,
      author       = {Johnson, Raphael and Nawroth, Thomas and Khoshakhlagh,
                      Pooneh and Langguth, Peter and Schmueser, Lars and Hellmann,
                      Nadja and Decker, Heinz and Szekely, Noemi},
      title        = {{A}mphotericin {B} microparticles ‘{A}mbi{S}hell’
                      from phospholipid and gelatin: {D}evelopment and
                      investigation by combined {DLS} and {SANS} resolves the
                      core-shell structure},
      journal      = {European journal of lipid science and technology},
      volume       = {116},
      number       = {9},
      issn         = {1438-7697},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2014-06861},
      pages        = {1167 - 1173},
      year         = {2014},
      abstract     = {A novel homogenous core-shell formulation ‘AmbiShell’
                      of the hydrophobic antifungal polyene drug Amphotericin B
                      was prepared from the pure drug, lecithin, and gelatin. The
                      established ‘Hydrophilic Solubilisation Technology’
                      (HST) was used for embedding the lipophilic drug with
                      lecithin and gelatin, yielding core-shell microparticles of
                      1 µm size. The particle size of the drug, the
                      formulation, and the thickness of the coating were
                      investigated by using dynamic light scattering (DLS),
                      microscopy, UV–Visible spectroscopy and small angle
                      neutron scattering (SANS). The drug in the formulation was
                      not in the oligomer form but in a competent uptake form, as
                      shown by the UV–Visible spectroscopy. The DLS and
                      microscopy depicted the product to consist of spheres
                      (∼1 µm). The SANS experiment using deuterium contrast
                      matching of the drug cores revealed a thin layer span of
                      5.6 nm, which is similar, but slightly larger as compared
                      to the biological lipid membranes. The finding offers
                      opportunities for further improvements of the formulation,
                      e.g., by surface modification.A soluble core-shell
                      formulation ‘AmbiShell’ of the hydrophobic antifungal
                      polyene drug Amphotericin B was generated from drug,
                      lecithin, and gelatin. The span of the lipid–gelatin shell
                      was estimated by neutron scattering SANS with deuterium
                      contrast matching of the drug core.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1 /
                      ICS-1},
      ddc          = {660},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)ICS-1-20110106},
      pnm          = {54G - JCNS (POF2-54G24)},
      pid          = {G:(DE-HGF)POF2-54G24},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000343000600009},
      doi          = {10.1002/ejlt.201400069},
      url          = {https://juser.fz-juelich.de/record/183567},
}