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@ARTICLE{Khoshakhlagh:183570,
      author       = {Khoshakhlagh, Pooneh and Johnson, Raphael and Nawroth,
                      Thomas and Langguth, Peter and Schmueser, Lars and Hellmann,
                      Nadja and Decker, Heinz and Szekely, Noemi},
      title        = {{N}anoparticle structure development in the
                      gastro-intestinal model fluid {F}a{SSIF} mod6.5 from several
                      phospholipids at various water content relevant for oral
                      drug administration},
      journal      = {European journal of lipid science and technology},
      volume       = {116},
      number       = {9},
      issn         = {1438-7697},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2014-06864},
      pages        = {1155 - 1166},
      year         = {2014},
      abstract     = {The characteristics of intestinal model fluids were
                      investigated at conditions, which simulate the passage from
                      the middle to the end of the duodenum. The formation and
                      decay of liposomes and micelles in model bile fluids were
                      studied, because of their role as an intermediate host for
                      the resolution and uptake of hydrophobic drugs (BCS classes
                      II, IV). The conditions, which may influence the formation
                      of these nanoparticulate intermediates were studied, i.e.,
                      the lipid composition of the bile, the preparation method,
                      the time of the passage through the modelled duodenum
                      segment and the concentration, which results from the
                      variable dilution of the bile by mixing with the transfer
                      medium representing the fluid arriving from the stomach. The
                      variation of the lecithin entity revealed an equivalence of
                      Egg–lecithin of a high purity $(99\%)$ with its main
                      component 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
                      POPC, while 1,2-di-oleoyl-sn-glycero-3-phosphocholine DOPC
                      resulted in a slight delay of the micelle-liposome
                      conversion. The FeSSIF preparation method was best with the
                      sequential-film method, while the bile-film method yielded
                      comparable results; the shake method showed a slightly
                      different kinetics of the nanoparticle conversion. The time
                      and concentration dependence of the formation and decay of
                      lipidic nanoparticles indicates that these strongly depend
                      on the passage time (speed) and bile dilution rate. The
                      corresponding physiological conditions at healthy persons
                      may vary in vivo individually and due to diseases. The
                      studied conditions cover typical physiological conditions,
                      which should be taken into consideration in the exploration
                      of in vitro tests of formulations of hydrophobic
                      drugs.Formation and decay of liposomes and micelles from
                      bile in the duodenum was studied, due to their role as an
                      intermediate for resolution and uptake of hydrophobic drugs
                      (BCS II, IV). The physiological conditions studied may vary
                      individually and due to diseases.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1 /
                      ICS-1},
      ddc          = {660},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)ICS-1-20110106},
      pnm          = {54G - JCNS (POF2-54G24)},
      pid          = {G:(DE-HGF)POF2-54G24},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000343000600008},
      doi          = {10.1002/ejlt.201400066},
      url          = {https://juser.fz-juelich.de/record/183570},
}