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000018375 1001_ $$0P:(DE-Juel1)131684$$aHoffstaedter, F.$$b0$$uFZJ
000018375 245__ $$aInternally vs. externally triggered movements in patients with major depression
000018375 260__ $$aAmsterdam$$bElsevier$$c2012
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000018375 440_0 $$0768$$aBehavioural Brain Research$$v228$$x0166-4328
000018375 500__ $$aThis work was partly funded by the Human Brain Project (R01-MH074457-01A1; S.B.E.), the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (Human Brain Model; S.B.E.) and the DFG (IRTG 1328, S.B.E.).
000018375 520__ $$aPsychomotor retardation is a prominent clinical feature of major depression. While several studies investigated these deficits, differences between internally and externally triggered response selection and initiation are less well understood. In the current study, we delineate internally vs. externally driven response selection and initiation in depression and their relation to basic psychomotor functioning.20 inpatients diagnosed with a (unipolar) major depression and 20 closely matched healthy controls performed a computerized motor paradigm assessing differences between internally and externally cued movements. Psychomotor performance and basic memory functions were assessed using a neuropsychological test-battery. To examine within group homogeneity a multivariate clustering approach was applied.Patients featured a global slowing of internally and externally cued response selection compared to controls, as well as impairments in basic psychomotor functioning. Yet, basic motor speed was preserved. Furthermore, patients were more severely impaired when movements involved internal response selection. The data-driven clustering revealed two patient subgroups, which both showed psychomotor disturbances, while only one featured slowing of response selection.The results suggest a differential rather than a global psychomotor slowing in major depression with specific impairments of visuospatial and attentional processing as cognitive aspects of psychomotor functioning. As found for depression, in Parkinson's disease internally cued movements are more severely affected than externally cued reactions. Both may therefore be caused by dopaminergic deregulation due to frontostriatal deficits. Finally, multivariate clustering of behavioral data may be a promising future approach to identify subtypes of psychomotor or cognitive disturbances in different patient populations.
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000018375 65320 $$2Author$$aResponse selection
000018375 65320 $$2Author$$aDepression
000018375 65320 $$2Author$$aPsychomotor deficits
000018375 65320 $$2Author$$aCognitive deficits
000018375 65320 $$2Author$$aMultivariate clustering
000018375 650_2 $$2MeSH$$aAdolescent
000018375 650_2 $$2MeSH$$aAdult
000018375 650_2 $$2MeSH$$aAged
000018375 650_2 $$2MeSH$$aAntidepressive Agents: pharmacology
000018375 650_2 $$2MeSH$$aAntidepressive Agents: therapeutic use
000018375 650_2 $$2MeSH$$aAptitude Tests: statistics & numerical data
000018375 650_2 $$2MeSH$$aCase-Control Studies
000018375 650_2 $$2MeSH$$aCues
000018375 650_2 $$2MeSH$$aDepressive Disorder, Major: diagnosis
000018375 650_2 $$2MeSH$$aDepressive Disorder, Major: drug therapy
000018375 650_2 $$2MeSH$$aDepressive Disorder, Major: physiopathology
000018375 650_2 $$2MeSH$$aFemale
000018375 650_2 $$2MeSH$$aHumans
000018375 650_2 $$2MeSH$$aMale
000018375 650_2 $$2MeSH$$aMiddle Aged
000018375 650_2 $$2MeSH$$aMovement: drug effects
000018375 650_2 $$2MeSH$$aMovement: physiology
000018375 650_2 $$2MeSH$$aNeuropsychological Tests: statistics & numerical data
000018375 650_2 $$2MeSH$$aPsychomotor Performance: drug effects
000018375 650_2 $$2MeSH$$aPsychomotor Performance: physiology
000018375 650_2 $$2MeSH$$aSeverity of Illness Index
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000018375 7001_ $$0P:(DE-HGF)0$$aSarlon, J.$$b1
000018375 7001_ $$0P:(DE-HGF)0$$aGrefkes, C.$$b2
000018375 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S.B.$$b3$$uFZJ
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