TY  - JOUR
AU  - Hoffstaedter, F.
AU  - Sarlon, J.
AU  - Grefkes, C.
AU  - Eickhoff, S.B.
TI  - Internally vs. externally triggered movements in patients with major depression
JO  - Behavioural brain research
VL  - 228
SN  - 0166-4328
CY  - Amsterdam
PB  - Elsevier
M1  - PreJuSER-18375
SP  - 125 - 132
PY  - 2012
N1  - This work was partly funded by the Human Brain Project (R01-MH074457-01A1; S.B.E.), the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (Human Brain Model; S.B.E.) and the DFG (IRTG 1328, S.B.E.).
AB  - Psychomotor retardation is a prominent clinical feature of major depression. While several studies investigated these deficits, differences between internally and externally triggered response selection and initiation are less well understood. In the current study, we delineate internally vs. externally driven response selection and initiation in depression and their relation to basic psychomotor functioning.20 inpatients diagnosed with a (unipolar) major depression and 20 closely matched healthy controls performed a computerized motor paradigm assessing differences between internally and externally cued movements. Psychomotor performance and basic memory functions were assessed using a neuropsychological test-battery. To examine within group homogeneity a multivariate clustering approach was applied.Patients featured a global slowing of internally and externally cued response selection compared to controls, as well as impairments in basic psychomotor functioning. Yet, basic motor speed was preserved. Furthermore, patients were more severely impaired when movements involved internal response selection. The data-driven clustering revealed two patient subgroups, which both showed psychomotor disturbances, while only one featured slowing of response selection.The results suggest a differential rather than a global psychomotor slowing in major depression with specific impairments of visuospatial and attentional processing as cognitive aspects of psychomotor functioning. As found for depression, in Parkinson's disease internally cued movements are more severely affected than externally cued reactions. Both may therefore be caused by dopaminergic deregulation due to frontostriatal deficits. Finally, multivariate clustering of behavioral data may be a promising future approach to identify subtypes of psychomotor or cognitive disturbances in different patient populations.
KW  - Adolescent
KW  - Adult
KW  - Aged
KW  - Antidepressive Agents: pharmacology
KW  - Antidepressive Agents: therapeutic use
KW  - Aptitude Tests: statistics & numerical data
KW  - Case-Control Studies
KW  - Cues
KW  - Depressive Disorder, Major: diagnosis
KW  - Depressive Disorder, Major: drug therapy
KW  - Depressive Disorder, Major: physiopathology
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Movement: drug effects
KW  - Movement: physiology
KW  - Neuropsychological Tests: statistics & numerical data
KW  - Psychomotor Performance: drug effects
KW  - Psychomotor Performance: physiology
KW  - Severity of Illness Index
KW  - Antidepressive Agents (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:22142951
UR  - <Go to ISI:>//WOS:000300472600016
DO  - DOI:10.1016/j.bbr.2011.11.024
UR  - https://juser.fz-juelich.de/record/18375
ER  -