%0 Journal Article
%A Eickhoff, S. B.
%A Dafotakis, M.
%A Grefkes, M.
%A Stöcker, T.
%A Shah, J. N.
%A Schnitzler, A.
%A Zilles, K.
%A Siebler, M.
%T fMRI reveals cognitive and emotional processing in a long-term comatose patient
%J Experimental neurology
%V 214
%@ 0014-4886
%C Amsterdam [u.a.]
%I Elsevier
%M PreJuSER-1852
%P 240 - 246
%D 2008
%Z This Human Brain Project/Neuroinformatics research was funded by the NIBIB, NINDS and NIMH. K.Z. acknowledges funding by the Deutsche Forschungsgemeinschaft (KFO-112) and the Volkswagenstiftung.
%X We report on a 41-year old woman with prolonged comatose unresponsiveness following traumatic head injury. Structural MRI showed bilateral midbrain damage and ventriculomegalia. Functional MRI revealed robust cortical responses to visual, auditory and tactile stimulation. Speech stimuli moreover consistently elicited activation in Broca's and Wernicke's areas. Familiar speakers and direct addressing evoked significantly stronger amygdala activation than unfamiliar speakers and neutral phrases. This study hence demonstrates the potential of functional neuroimaging in the investigation of residual higher cortical functions in unresponsive comatose patients.
%K Acoustic Stimulation
%K Adult
%K Amygdala: physiology
%K Cognition: physiology
%K Coma: physiopathology
%K Emotions: physiology
%K Female
%K Frontal Lobe: physiology
%K Humans
%K Magnetic Resonance Imaging
%K Persistent Vegetative State: physiopathology
%K Photic Stimulation
%K Physical Stimulation
%K Speech Perception: physiology
%K Temporal Lobe: physiology
%K J (WoSType)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:18789930
%U <Go to ISI:>//WOS:000261483900010
%R 10.1016/j.expneurol.2008.08.007
%U https://juser.fz-juelich.de/record/1852