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000001852 0247_ $$2DOI$$a10.1016/j.expneurol.2008.08.007
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000001852 041__ $$aeng
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000001852 084__ $$2WoS$$aNeurosciences
000001852 1001_ $$0P:(DE-Juel1)131678$$aEickhoff, S. B.$$b0$$uFZJ
000001852 245__ $$afMRI reveals cognitive and emotional processing in a long-term comatose patient
000001852 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2008
000001852 300__ $$a240 - 246
000001852 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000001852 440_0 $$02033$$aExperimental Neurology$$v214$$x0014-4886$$y2
000001852 500__ $$aThis Human Brain Project/Neuroinformatics research was funded by the NIBIB, NINDS and NIMH. K.Z. acknowledges funding by the Deutsche Forschungsgemeinschaft (KFO-112) and the Volkswagenstiftung.
000001852 520__ $$aWe report on a 41-year old woman with prolonged comatose unresponsiveness following traumatic head injury. Structural MRI showed bilateral midbrain damage and ventriculomegalia. Functional MRI revealed robust cortical responses to visual, auditory and tactile stimulation. Speech stimuli moreover consistently elicited activation in Broca's and Wernicke's areas. Familiar speakers and direct addressing evoked significantly stronger amygdala activation than unfamiliar speakers and neutral phrases. This study hence demonstrates the potential of functional neuroimaging in the investigation of residual higher cortical functions in unresponsive comatose patients.
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000001852 65320 $$2Author$$aTrauma
000001852 65320 $$2Author$$aLanguage
000001852 65320 $$2Author$$aEmotion
000001852 65320 $$2Author$$aPersistent vegetative state
000001852 65320 $$2Author$$aMinimally conscious state
000001852 650_2 $$2MeSH$$aAcoustic Stimulation
000001852 650_2 $$2MeSH$$aAdult
000001852 650_2 $$2MeSH$$aAmygdala: physiology
000001852 650_2 $$2MeSH$$aCognition: physiology
000001852 650_2 $$2MeSH$$aComa: physiopathology
000001852 650_2 $$2MeSH$$aEmotions: physiology
000001852 650_2 $$2MeSH$$aFemale
000001852 650_2 $$2MeSH$$aFrontal Lobe: physiology
000001852 650_2 $$2MeSH$$aHumans
000001852 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000001852 650_2 $$2MeSH$$aPersistent Vegetative State: physiopathology
000001852 650_2 $$2MeSH$$aPhotic Stimulation
000001852 650_2 $$2MeSH$$aPhysical Stimulation
000001852 650_2 $$2MeSH$$aSpeech Perception: physiology
000001852 650_2 $$2MeSH$$aTemporal Lobe: physiology
000001852 650_7 $$2WoSType$$aJ
000001852 7001_ $$0P:(DE-Juel1)VDB58058$$aDafotakis, M.$$b1$$uFZJ
000001852 7001_ $$0P:(DE-HGF)0$$aGrefkes, M.$$b2
000001852 7001_ $$0P:(DE-Juel1)VDB18939$$aStöcker, T.$$b3$$uFZJ
000001852 7001_ $$0P:(DE-Juel1)131794$$aShah, J. N.$$b4$$uFZJ
000001852 7001_ $$0P:(DE-HGF)0$$aSchnitzler, A.$$b5
000001852 7001_ $$0P:(DE-Juel1)131714$$aZilles, K.$$b6$$uFZJ
000001852 7001_ $$0P:(DE-Juel1)VDB5583$$aSiebler, M.$$b7$$uFZJ
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