TY  - JOUR
AU  - Eickhoff, S. B.
AU  - Dafotakis, M.
AU  - Grefkes, M.
AU  - Stöcker, T.
AU  - Shah, J. N.
AU  - Schnitzler, A.
AU  - Zilles, K.
AU  - Siebler, M.
TI  - fMRI reveals cognitive and emotional processing in a long-term comatose patient
JO  - Experimental neurology
VL  - 214
SN  - 0014-4886
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - PreJuSER-1852
SP  - 240 - 246
PY  - 2008
N1  - This Human Brain Project/Neuroinformatics research was funded by the NIBIB, NINDS and NIMH. K.Z. acknowledges funding by the Deutsche Forschungsgemeinschaft (KFO-112) and the Volkswagenstiftung.
AB  - We report on a 41-year old woman with prolonged comatose unresponsiveness following traumatic head injury. Structural MRI showed bilateral midbrain damage and ventriculomegalia. Functional MRI revealed robust cortical responses to visual, auditory and tactile stimulation. Speech stimuli moreover consistently elicited activation in Broca's and Wernicke's areas. Familiar speakers and direct addressing evoked significantly stronger amygdala activation than unfamiliar speakers and neutral phrases. This study hence demonstrates the potential of functional neuroimaging in the investigation of residual higher cortical functions in unresponsive comatose patients.
KW  - Acoustic Stimulation
KW  - Adult
KW  - Amygdala: physiology
KW  - Cognition: physiology
KW  - Coma: physiopathology
KW  - Emotions: physiology
KW  - Female
KW  - Frontal Lobe: physiology
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Persistent Vegetative State: physiopathology
KW  - Photic Stimulation
KW  - Physical Stimulation
KW  - Speech Perception: physiology
KW  - Temporal Lobe: physiology
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:18789930
UR  - <Go to ISI:>//WOS:000261483900010
DO  - DOI:10.1016/j.expneurol.2008.08.007
UR  - https://juser.fz-juelich.de/record/1852
ER  -