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@ARTICLE{Bihr:185538,
author = {Bihr, Timo and Fenz, Susanne and Sackmann, Erich and
Merkel, Rudolf and Seifert, Udo and Sengupta, Kheya and
Smith, Ana-Sunčana},
title = {{A}ssociation {R}ates of {M}embrane-{C}oupled {C}ell
{A}dhesion {M}olecules},
journal = {Biophysical journal},
volume = {107},
number = {11},
issn = {0006-3495},
address = {New York, NY},
publisher = {Rockefeller Univ. Press},
reportid = {FZJ-2014-06965},
pages = {L33 - L36},
year = {2014},
abstract = {Thus far, understanding how the confined cellular
environment affects the lifetime of bonds, as well as the
extraction of complexation rates, has been a major challenge
in studies of cell adhesion. Based on a theoretical
description of the growth curves of adhesion domains, we
present a new (to our knowledge) method to measure the
association rate kon of ligand-receptor pairs incorporated
into lipid membranes. As a proof of principle, we apply this
method to several systems. We find that the kon for the
interaction of biotin with neutravidin is larger than that
for integrin binding to RGD or sialyl Lewisx to E-selectin.
Furthermore, we find kon to be enhanced by membrane
fluctuations that increase the probability for encounters
between the binders. The opposite effect on kon could be
attributed to the presence of repulsive polymers that mimic
the glycocalyx, which points to two potential mechanisms for
controlling the speed of protein complexation during the
cell recognition process.},
cin = {ICS-7},
ddc = {570},
cid = {I:(DE-Juel1)ICS-7-20110106},
pnm = {453 - Physics of the Cell (POF2-453)},
pid = {G:(DE-HGF)POF2-453},
experiment = {EXP:(DE-MLZ)NOSPEC-20140101},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000345859500002},
pubmed = {pmid:25468354},
doi = {10.1016/j.bpj.2014.10.033},
url = {https://juser.fz-juelich.de/record/185538},
}