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@ARTICLE{Bihr:185538,
      author       = {Bihr, Timo and Fenz, Susanne and Sackmann, Erich and
                      Merkel, Rudolf and Seifert, Udo and Sengupta, Kheya and
                      Smith, Ana-Sunčana},
      title        = {{A}ssociation {R}ates of {M}embrane-{C}oupled {C}ell
                      {A}dhesion {M}olecules},
      journal      = {Biophysical journal},
      volume       = {107},
      number       = {11},
      issn         = {0006-3495},
      address      = {New York, NY},
      publisher    = {Rockefeller Univ. Press},
      reportid     = {FZJ-2014-06965},
      pages        = {L33 - L36},
      year         = {2014},
      abstract     = {Thus far, understanding how the confined cellular
                      environment affects the lifetime of bonds, as well as the
                      extraction of complexation rates, has been a major challenge
                      in studies of cell adhesion. Based on a theoretical
                      description of the growth curves of adhesion domains, we
                      present a new (to our knowledge) method to measure the
                      association rate kon of ligand-receptor pairs incorporated
                      into lipid membranes. As a proof of principle, we apply this
                      method to several systems. We find that the kon for the
                      interaction of biotin with neutravidin is larger than that
                      for integrin binding to RGD or sialyl Lewisx to E-selectin.
                      Furthermore, we find kon to be enhanced by membrane
                      fluctuations that increase the probability for encounters
                      between the binders. The opposite effect on kon could be
                      attributed to the presence of repulsive polymers that mimic
                      the glycocalyx, which points to two potential mechanisms for
                      controlling the speed of protein complexation during the
                      cell recognition process.},
      cin          = {ICS-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-7-20110106},
      pnm          = {453 - Physics of the Cell (POF2-453)},
      pid          = {G:(DE-HGF)POF2-453},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000345859500002},
      pubmed       = {pmid:25468354},
      doi          = {10.1016/j.bpj.2014.10.033},
      url          = {https://juser.fz-juelich.de/record/185538},
}