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@ARTICLE{Schulz:185728,
      author       = {Schulz, Anita and Jaksch, Sebastian and Schubel, Rene and
                      Wegener, Erik and Di, Zhenyu and Han, Yingchao and Meister,
                      Annette and Kressler, Jörg and Kabanov, Alexander V. and
                      Luxenhofer, Robert and Papadakis, Christine M. and Jordan,
                      Rainer},
      title        = {{D}rug-{I}nduced {M}orphology {S}witch in {D}rug {D}elivery
                      {S}ystems {B}ased on {P}oly(2-oxazoline)s},
      journal      = {ACS nano},
      volume       = {8},
      number       = {3},
      issn         = {1936-086X},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {FZJ-2014-07153},
      pages        = {2686 - 2696},
      year         = {2014},
      abstract     = {Defined aggregates of polymers such as polymeric micelles
                      are of great importance in the development of pharmaceutical
                      formulations. The amount of drug that can be formulated by a
                      drug delivery system is an important issue, and most drug
                      delivery systems suffer from their relatively low
                      drug-loading capacity. However, as the loading capacities
                      increase, i.e., promoted by good drug–polymer
                      interactions, the drug may affect the morphology and
                      stability of the micellar system. We investigated this
                      effect in a prominent system with very high capacity for
                      hydrophobic drugs and found extraordinary stability as well
                      as a profound morphology change upon incorporation of
                      paclitaxel into micelles of amphiphilic ABA
                      poly(2-oxazoline) triblock copolymers. The hydrophilic
                      blocks A comprised poly(2-methyl-2-oxazoline), while the
                      middle blocks B were either just barely hydrophobic
                      poly(2-n-butyl-2-oxazoline) or highly hydrophobic
                      poly(2-n-nonyl-2-oxazoline). The aggregation behavior of
                      both polymers and their formulations with varying paclitaxel
                      contents were investigated by means of dynamic light
                      scattering, atomic force microscopy, (cryogenic)
                      transmission electron microscopy, and small-angle neutron
                      scattering. While without drug, wormlike micelles were
                      present, after incorporation of small amounts of drugs only
                      spherical morphologies remained. Furthermore, the much more
                      hydrophobic poly(2-n-nonyl-2-oxazoline)-containing triblock
                      copolymer exhibited only half the capacity for paclitaxel
                      than the poly(2-n-butyl-2-oxazoline)-containing copolymer
                      along with a lower stability. In the latter, contents of
                      paclitaxel of 8 wt $\%$ or higher resulted in a
                      raspberry-like micellar core.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1 /
                      ICS-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)ICS-1-20110106},
      pnm          = {54G - JCNS (POF2-54G24)},
      pid          = {G:(DE-HGF)POF2-54G24},
      experiment   = {EXP:(DE-MLZ)KWS1-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000333539400084},
      pubmed       = {pmid:24548260},
      doi          = {10.1021/nn406388t},
      url          = {https://juser.fz-juelich.de/record/185728},
}