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000186054 1001_ $$0P:(DE-HGF)0$$aQuy, Vo$$b0$$eCorresponding Author
000186054 245__ $$aHIV-1 Integrase Binding to its Cellular Partners: A Perspective from Computational Biology
000186054 260__ $$aHilversum$$bBentham Science Publ.$$c2014
000186054 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1420722914_9914
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000186054 520__ $$aViral DNA integration into the infected cell genome is an essential step in the HIV-1 life cycle. Hence, the viral integrase enzyme has become an important target for antiviral therapy. The integrase's activity action relies on the binding to its cellular partners, therefore the knowledge of the structural determinants is very important from a therapeutic perspective. Here we first review published computer-aided structural predictions of HIV-1 integrase in complex with its interactors. These include DNA and the human HAT protein. Next, we present a prediction of the complex between HIV-1 integrase with the human prolyl-isomerase-1 (hPin1) enzyme. Interaction with hPin1 is crucial for efficient HIV-1 infection and it increases integrase stability (Manganaro et. al 2010, Nat. Med. 16, 329). The modeling presented here, which is validated against experimental data, provides a rationale for a variety of viral protein's mutations which impair protein function and HIV-1 virus replication in vivo without significantly affecting enzymatic activity.
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000186054 7001_ $$0P:(DE-HGF)0$$aCarnevale, Vincenzo$$b1
000186054 7001_ $$0P:(DE-HGF)0$$aManganaro, Lara$$b2
000186054 7001_ $$0P:(DE-HGF)0$$aLusic, Marina$$b3
000186054 7001_ $$0P:(DE-Juel1)145921$$aRossetti, Giulia$$b4$$ufzj
000186054 7001_ $$0P:(DE-HGF)0$$aLeone, Vanessa$$b5
000186054 7001_ $$0P:(DE-HGF)0$$aFenollar-Ferrer, Cristina$$b6
000186054 7001_ $$0P:(DE-HGF)0$$aRaugei, Simone$$b7
000186054 7001_ $$0P:(DE-HGF)0$$aSal, Giannino$$b8
000186054 7001_ $$0P:(DE-HGF)0$$aGiacca, Mauro$$b9
000186054 7001_ $$0P:(DE-Juel1)145614$$aCarloni, Paolo$$b10$$ufzj
000186054 773__ $$0PERI:(DE-600)2034245-7$$a10.2174/13816128113199990631$$gVol. 20, no. 21, p. 3412 - 3421$$n21$$p3412 - 3421$$tCurrent pharmaceutical design$$v20$$x1381-6128$$y2014
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