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@ARTICLE{Dunkl:186057,
      author       = {Dunkl, V. and Cleff, C. and Stoffels, G. and Judov, N. and
                      Sarikaya-Seiwert, S. and Law, I. and Bogeskov, L. and Nysom,
                      K. and Andersen, S. B. and Steiger, H.-J. and Fink, G. R.
                      and Reifenberger, G. and Shah, N. J. and Coenen, H. H. and
                      Langen, K.-J. and Galldiks, N.},
      title        = {{T}he usefulness of dynamic
                      {O}-(2-18{F}-{F}luoroethyl)-{L}-{T}yrosine {PET} in the
                      clinical evaluation of brain tumors in childrenand
                      adolescents.},
      journal      = {Journal of nuclear medicine},
      volume       = {56},
      number       = {1},
      issn         = {0161-5505},
      address      = {Reston, Va.},
      publisher    = {SNM},
      reportid     = {FZJ-2015-00158},
      pages        = {88-92},
      year         = {2015},
      abstract     = {Experience regarding O-(2-18F-fluoroethyl)-l-tyrosine
                      (18F-FET) PET in children and adolescents with brain tumors
                      is limited. Methods: Sixty-nine 18F-FET PET scans of 48
                      children and adolescents (median age, 13 y; range, 1–18 y)
                      were analyzed retrospectively. Twenty-six scans to assess
                      newly diagnosed cerebral lesions, 24 scans for diagnosing
                      tumor progression or recurrence, 8 scans for monitoring of
                      chemotherapy effects, and 11 scans for the detection of
                      residual tumor after resection were obtained. Maximum and
                      mean tumor-to-brain ratios (TBRs) were determined at 20–40
                      min after injection, and time–activity curves of 18F-FET
                      uptake were assigned to 3 different patterns: constant
                      increase; peak at greater than 20–40 min after injection,
                      followed by a plateau; and early peak (≤20 min), followed
                      by a constant descent. The diagnostic accuracy of 18F-FET
                      PET was assessed by receiver-operating-characteristic curve
                      analyses using histology or clinical course as a reference.
                      Results: In patients with newly diagnosed cerebral lesions,
                      the highest accuracy $(77\%)$ to detect neoplastic tissue
                      (19/26 patients) was obtained when the maximum TBR was 1.7
                      or greater (area under the curve, 0.80 ± 0.09; sensitivity,
                      $79\%;$ specificity, $71\%;$ positive predictive value,
                      $88\%;$ P = 0.02). For diagnosing tumor progression or
                      recurrence, the highest accuracy $(82\%)$ was obtained when
                      curve patterns 2 or 3 were present (area under the curve,
                      0.80 ± 0.11; sensitivity, $75\%;$ specificity, $90\%;$
                      positive predictive value, $90\%;$ P = 0.02). During
                      chemotherapy, a decrease of TBRs was associated with a
                      stable clinical course, and in 2 patients PET detected
                      residual tumor after presumably complete tumor resection.
                      Conclusion: Our findings suggest that 18F-FET PET can add
                      valuable information for clinical decision making in
                      pediatric brain tumor patients.},
      cin          = {INM-3 / INM-4 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000347233700034},
      pubmed       = {pmid:25525183},
      doi          = {10.2967/jnumed.114.148734},
      url          = {https://juser.fz-juelich.de/record/186057},
}