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@ARTICLE{Prez:186177,
      author       = {Pérez, Javier and Koutsioumpas, Alexandros},
      title        = {{M}emprot: a program to model the detergent corona around a
                      membrane protein based on {SEC}-{SAXS} data},
      journal      = {Acta crystallographica / D},
      volume       = {71},
      number       = {1},
      issn         = {1399-0047},
      address      = {Copenhagen},
      publisher    = {Munksgaard},
      reportid     = {FZJ-2015-00265},
      pages        = {86 - 93},
      year         = {2015},
      abstract     = {The application of small-angle X-ray scattering (SAXS) to
                      structural investigations of transmembrane proteins in
                      detergent solution has been hampered by two main inherent
                      hurdles. On the one hand, the formation of a detergent
                      corona around the hydrophobic region of the protein strongly
                      modifies the scattering curve of the protein. On the other
                      hand, free micelles of detergent without a precisely known
                      concentration coexist with the protein-detergent complex in
                      solution, therefore adding an uncontrolled signal. To gain
                      robust structural information on such systems from SAXS
                      data, in previous work, advantage was taken of the online
                      combination of size-exclusion chromatography (SEC) and SAXS,
                      and the detergent corona around aquaporin-0, a membrane
                      protein of known structure, could be modelled. A precise
                      geometrical model of the corona, shaped as an elliptical
                      torus, was determined. Here, in order to better understand
                      the correlations between the corona model parameters and to
                      discuss the uniqueness of the model, this work was revisited
                      by analyzing systematic SAXS simulations over a wide range
                      of parameters of the torus.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1 /
                      ICS-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)ICS-1-20110106},
      pnm          = {6215 - Soft Matter, Health and Life Sciences (POF3-621) /
                      6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6215 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)External-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000348563900010},
      pubmed       = {pmid:25615863},
      doi          = {10.1107/S1399004714016678},
      url          = {https://juser.fz-juelich.de/record/186177},
}