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@ARTICLE{Mathys:186196,
      author       = {Mathys, Christian and Hoffstaedter, Felix and Caspers,
                      Julian and Caspers, Svenja and Südmeyer, Martin and
                      Grefkes, Christian and Eickhoff, Simon and Langner, Robert},
      title        = {{A}n age-related shift of resting-state functional
                      connectivity of the subthalamic nucleus: a potential
                      mechanism for compensating motor performance decline in
                      older adults},
      journal      = {Frontiers in aging neuroscience},
      volume       = {6},
      issn         = {1663-4365},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2015-00280},
      pages        = {178},
      year         = {2014},
      abstract     = {Healthy aging is associated with decline in basic motor
                      functioning and higher motor control. Here, we investigated
                      age-related differences in the brain-wide functional
                      connectivity (FC) pattern of the subthalamic nucleus (STN),
                      which plays an important role in motor response control. As
                      earlier studies revealed functional coupling between STN and
                      basal ganglia, which both are known to influence the
                      conservativeness of motor responses on a superordinate
                      level, we tested the hypothesis that STN FC with the
                      striatum becomes dysbalanced with age. To this end, we
                      performed a seed-based resting-state analysis of fMRI data
                      from 361 healthy adults (mean age: 41.8, age range: 18–85)
                      using bilateral STN as the seed region of interest. Age was
                      included as a covariate to identify regions showing
                      age-related changes of FC with the STN seed. The analysis
                      revealed positive FC of the STN with several previously
                      described subcortical and cortical regions like the anterior
                      cingulate and sensorimotor cortex, as well as not-yet
                      reported regions including central and posterior insula.
                      With increasing age, we observed reduced positive FC with
                      caudate nucleus, thalamus, and insula as well as increased
                      positive FC with sensorimotor cortex and putamen.
                      Furthermore, an age-related reduction of negative FC was
                      found with precuneus and posterior cingulate cortex. We
                      suggest that this reduced de-coupling of brain areas
                      involved in self-relevant but motor-unrelated cognitive
                      processing (i.e. precuneus and posterior cingulate cortex)
                      from the STN motor network may represent a potential
                      mechanism behind the age-dependent decline in motor
                      performance. At the same time, older adults appear to
                      compensate for this decline by releasing superordinate motor
                      control areas, in particular caudate nucleus and insula,
                      from STN interference while increasing STN-mediated response
                      control over lower level motor areas like sensorimotor
                      cortex and putamen.},
      cin          = {INM-3 / INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-1-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000340898200002},
      pubmed       = {pmid:25100995},
      doi          = {10.3389/fnagi.2014.00178},
      url          = {https://juser.fz-juelich.de/record/186196},
}