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@ARTICLE{Cieslik:186278,
      author       = {Cieslik, Edna and Müller, Veronika and Kellermann, Tanja
                      S. and Grefkes, Christian and Halfter, Sarah and Eickhoff,
                      Simon},
      title        = {{S}hifted neuronal balance during stimulus-response
                      integration in schizophrenia: an f{MRI} study},
      journal      = {Brain structure $\&$ function},
      volume       = {220},
      number       = {1},
      issn         = {1863-2661},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {FZJ-2015-00362},
      pages        = {249 - 261},
      year         = {2015},
      abstract     = {Schizophrenia is characterized by marked deficits in
                      executive and psychomotor functions, as demonstrated for
                      goal-directed actions in the antisaccade task. Recent
                      studies, however, suggest that this deficit represents only
                      one manifestation of a general deficit in
                      stimulus–response integration and volitional initiation of
                      motor responses. We here used functional magnetic resonance
                      imaging to investigate brain activation patterns during a
                      manual stimulus–response compatibility task in 18
                      schizophrenic patients and 18 controls. We found that across
                      groups incongruent vs. congruent responses recruited a
                      bilateral network consisting of dorsal fronto-parietal
                      circuits as well as bilateral anterior insula, dorsolateral
                      prefrontal cortex (DLPFC) and the presupplementary motor
                      area (preSMA). When testing for the main-effect across all
                      conditions, patients showed significantly lower activation
                      of the right DLPFC and, in turn, increased activation in a
                      left hemispheric network including parietal and premotor
                      areas as well as the preSMA. For incongruent responses
                      patients showed significantly increased activation in a
                      similar left hemispheric network, as well as additional
                      activation in parietal and premotor regions in the right
                      hemisphere. The present study reveals that hypoactivity in
                      the right DLPFC in schizophrenic patients is accompanied by
                      hyperactivity in several fronto-parietal regions associated
                      with task execution. Impaired top-down control due to a
                      dysfunctional DLPFC might thus be partly compensated by an
                      up-regulation of task-relevant regions in schizophrenic
                      patients},
      cin          = {INM-1 / JARA-BRAIN / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / $I:(DE-82)080010_20140620$ /
                      I:(DE-Juel1)INM-3-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000348980800018},
      doi          = {10.1007/s00429-013-0652-1},
      url          = {https://juser.fz-juelich.de/record/186278},
}