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@ARTICLE{Geisler:186448,
      author       = {Geisler, Stefanie and Ermert, Johannes and Stoffels,
                      Gabriele and Willuweit, Antje and Galldiks, Norbert and
                      Filss, Christian and Shah, N. J. and Coenen, Heinrich Hubert
                      and Langen, Karl-Josef},
      title        = {{I}somers of 4-[18{F}]fluoro-proline: radiosynthesis,
                      biological evaluation and results in humans using {PET}},
      journal      = {Current radiopharmaceuticals},
      volume       = {7},
      issn         = {1874-4710},
      address      = {Sharjah},
      publisher    = {Bentham Science Publ.},
      reportid     = {FZJ-2015-00522},
      pages        = {123-132},
      year         = {2014},
      abstract     = {Proline and hydroxyproline represent major constituents of
                      mammalian structural proteins, especially of collagen. An
                      efficient radiosynthesis of the (18)F-labeled proline
                      derivatives cis-/trans-4-[(18)F]fluoro-L-proline was
                      developed two decades ago with the aim to investigate
                      various diseases with altered collagen synthesis using
                      Positron-Emission- Tomography (PET). A number of studies
                      have explored cis-4-[(18)F]fluoro-L-proline uptake in
                      various pathologies associated with increased collagen
                      formation and in neoplastic lesions, but so far the results
                      have not been very promising.
                      Trans-4-[(18)F]fluoro-L-proline has not yet been
                      investigated in detail, however the compound exhibits
                      considerable differences in metabolic behavior and
                      biodistribution compared with its cis-enantiomer. In recent
                      years, the D-isomers of cis- /trans-4-[(18)F]fluoro-proline
                      have been considered as PET tracers as well, and it was
                      observed that both exhibit a preferred uptake into the brain
                      compared with their L-isomers. Surprisingly, a high uptake
                      of cis-4-[(18)F]fluoro-D-proline was found in brain areas
                      exhibiting secondary neurodegeneration as well as in areas
                      of radionecrosis after treatment of brain tumors. In this
                      article, the present knowledge on the biological and
                      physiological properties of
                      cis-/trans-4-[(18)F]fluoro-D/L-proline and the results in
                      various pathologies are reviewed, including some previously
                      unpublished results from our laboratory.},
      cin          = {INM-3 / INM-4 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      url          = {https://juser.fz-juelich.de/record/186448},
}