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@ARTICLE{Marel:186480,
      author       = {Marel, Anna-Kristina and Podewitz, Nils and Zorn, Matthias
                      and Rädler, Joachim Oskar and Elgeti, Jens},
      title        = {{A}lignment of cell division axes in directed epithelial
                      cell migration},
      journal      = {New journal of physics},
      volume       = {16},
      number       = {11},
      issn         = {1367-2630},
      address      = {[Bad Honnef]},
      publisher    = {Dt. Physikalische Ges.},
      reportid     = {FZJ-2015-00554},
      pages        = {115005 -},
      year         = {2014},
      abstract     = {Cell division is an essential dynamic event in tissue
                      remodeling during wound healing, cancer and embryogenesis.
                      In collective migration, tensile stresses affect cell shape
                      and polarity, hence, the orientation of the cell division
                      axis is expected to depend on cellular flow patterns. Here,
                      we study the degree of orientation of cell division axes in
                      migrating and resting epithelial cell sheets. We use
                      microstructured channels to create a defined scenario of
                      directed cell invasion and compare this situation to resting
                      but proliferating cell monolayers. In experiments, we find a
                      strong alignment of the axis due to directed flow while
                      resting sheets show very weak global order, but local flow
                      gradients still correlate strongly with the cell division
                      axis. We compare experimental results with a previously
                      published mesoscopic particle based simulation model. Most
                      of the observed effects are reproduced by the simulations.},
      cin          = {ICS-2},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ICS-2-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000346714200001},
      doi          = {10.1088/1367-2630/16/11/115005},
      url          = {https://juser.fz-juelich.de/record/186480},
}