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@ARTICLE{Firk:186564,
      author       = {Firk, C. and Mainz, V. and Schulte-Rüther, M. and Fink, G.
                      R. and Herpertz-Dahlmann, B. and Konrad, K.},
      title        = {{I}mplicit sequence learning in juvenile anorexia nervosa:
                      {N}eural mechanisms and the impact of starvation.},
      journal      = {Journal of Child Psychology $\&$ Psychiatry},
      volume       = {56},
      number       = {11},
      issn         = {0021-9630},
      address      = {Malden},
      publisher    = {Blackwell Publishing Limited},
      reportid     = {FZJ-2015-00637},
      pages        = {1168-1176},
      year         = {2015},
      abstract     = {BackgroundPrevious studies have reported that cognitive
                      deficits occur in patients with anorexia nervosa (AN) and
                      that these deficits may represent a predisposition towards
                      developing AN or perpetuate the disorder. Specifically,
                      dysfunctional implicit learning may contribute to the
                      development of highly resistant dieting behaviours that are
                      fundamental to the persistence of the disorder. Thus, the
                      aims of this study were (a) to investigate implicit sequence
                      learning in adolescent patients with AN before and after
                      weight recovery and (b) to elucidate the associated neural
                      mechanisms in acute AN relative to healthy
                      controls.MethodsIn a behavioural study, implicit sequence
                      learning was assessed using a serial reaction time task in
                      27 adolescents with AN before (T1) and after weight recovery
                      (T2) compared with age-matched healthy controls (HC) who
                      were assessed at similar time intervals. The neural
                      correlates of implicit sequence learning were subsequently
                      investigated in 19 AN patients shortly after they were
                      admitted to the hospital and 20 HC using functional magnetic
                      resonance imaging (fMRI).ResultsAt T1, AN patients showed
                      reduced sequence learning compared with HC. However, no
                      behavioural differences between HC and AN patients were
                      found at T2. At the neural level, acute AN patients showed
                      reduced thalamic activation during sequence learning
                      compared with HC subjects.ConclusionsOur data suggest that
                      the impaired implicit learning observed in adolescent AN
                      patients before weight gain is a state-related dysfunction
                      that normalises with weight gain. Thus, implicit learning
                      deficits do not appear to represent a predisposition towards
                      developing AN; rather, these deficits should be considered
                      when planning psychotherapeutic interventions for acute AN.
                      Reduced thalamic activation during the acute stage of AN may
                      indicate a starvation-induced dysfunction of the neural
                      circuitry that is involved in behavioural flexibility.},
      cin          = {INM-3},
      ddc          = {050},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000365411200004},
      pubmed       = {pmid:25623396},
      doi          = {10.1111/jcpp.12384},
      url          = {https://juser.fz-juelich.de/record/186564},
}