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000186575 1001_ $$0P:(DE-Juel1)140264$$aRinklin, Philipp$$b0$$ufzj
000186575 245__ $$aInducing microscopic thermal lesions for the dissection of functional cell networks on a chip
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000186575 520__ $$aWe present a versatile chip-based method to inflict microscopic lesions on cellular networks or tissue models. Our approach relies on resistive heating of microstructured conductors to impose highly localized thermal stress on specific regions of a cell network. We show that networks can be precisely dissected into individual subnetworks using a microwire crossbar array. To this end, we pattern a network of actively beating cardiomyocyte-like cells into smaller subunits by inflicting thermal damage along selected wires of the array. We then investigate the activity and functional connectivity of the individual subnetworks using a Ca2+ imaging-based signal propagation analysis. Our results demonstrate the efficient separation of func- tional activity between individual subnetworks on a microscopic level. We believe that the presented tech- nique may become a powerful tool for investigating lesion and regeneration models in cellular networks.
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000186575 7001_ $$0P:(DE-Juel1)144600$$aAfanasenkau, Dzmitry$$b1$$ufzj
000186575 7001_ $$0P:(DE-Juel1)131034$$aWiegand, Simone$$b2$$ufzj
000186575 7001_ $$0P:(DE-Juel1)128713$$aOffenhäusser, Andreas$$b3$$ufzj
000186575 7001_ $$0P:(DE-Juel1)128745$$aWolfrum, Bernhard$$b4$$eCorresponding Author$$ufzj
000186575 773__ $$0PERI:(DE-600)2056646-3$$a10.1039/C4LC00805G$$gVol. 15, no. 1, p. 237 - 243$$n1$$p237 - 243$$tLab on a chip$$v15$$x1473-0189$$y2015
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