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@ARTICLE{Rinklin:186575,
      author       = {Rinklin, Philipp and Afanasenkau, Dzmitry and Wiegand,
                      Simone and Offenhäusser, Andreas and Wolfrum, Bernhard},
      title        = {{I}nducing microscopic thermal lesions for the dissection
                      of functional cell networks on a chip},
      journal      = {Lab on a chip},
      volume       = {15},
      number       = {1},
      issn         = {1473-0189},
      address      = {Cambridge},
      publisher    = {RSC},
      reportid     = {FZJ-2015-00648},
      pages        = {237 - 243},
      year         = {2015},
      abstract     = {We present a versatile chip-based method to inflict
                      microscopic lesions on cellular networks or tissue models.
                      Our approach relies on resistive heating of microstructured
                      conductors to impose highly localized thermal stress on
                      specific regions of a cell network. We show that networks
                      can be precisely dissected into individual subnetworks using
                      a microwire crossbar array. To this end, we pattern a
                      network of actively beating cardiomyocyte-like cells into
                      smaller subunits by inflicting thermal damage along selected
                      wires of the array. We then investigate the activity and
                      functional connectivity of the individual subnetworks using
                      a Ca2+ imaging-based signal propagation analysis. Our
                      results demonstrate the efficient separation of func- tional
                      activity between individual subnetworks on a microscopic
                      level. We believe that the presented tech- nique may become
                      a powerful tool for investigating lesion and regeneration
                      models in cellular networks.},
      cin          = {PGI-8 / JARA-FIT},
      ddc          = {004},
      cid          = {I:(DE-Juel1)PGI-8-20110106 / $I:(DE-82)080009_20140620$},
      pnm          = {552 - Engineering Cell Function (POF3-552) / Helmholtz
                      Young Investigators Group (HGF-YoungInvestigatorsGroup)},
      pid          = {G:(DE-HGF)POF3-552 / G:(DE-HGF)HGF-YoungInvestigatorsGroup},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000346478100028},
      pubmed       = {pmid:25358015},
      doi          = {10.1039/C4LC00805G},
      url          = {https://juser.fz-juelich.de/record/186575},
}