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@ARTICLE{Adamchic:187655,
      author       = {Adamchic, Ilya and Langguth, Berthold and Hauptmann,
                      Christian and Tass, Peter A.},
      title        = {{A}bnormal cross-frequency coupling in the tinnitus
                      network},
      journal      = {Frontiers in neuroscience},
      volume       = {8},
      issn         = {1662-453X},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2015-01281},
      pages        = {284},
      year         = {2014},
      abstract     = {Neuroimaging studies have identified networks of brain
                      areas and oscillations associated with tinnitus perception.
                      However, how these regions relate to perceptual
                      characteristics of tinnitus, and how oscillations in various
                      frequency bands are associated with communications within
                      the tinnitus network is still incompletely understood.
                      Recent evidence suggests that apart from changes of the
                      tinnitus severity the changes of tinnitus dominant pitch
                      also have modulating effect on the underlying neuronal
                      activity in a number of brain areas within the tinnitus
                      network. Therefore, in a re-analysis of an existing dataset,
                      we sought to determine how the oscillations in the tinnitus
                      network in the various frequency bands interact. We also
                      investigate how changes of tinnitus loudness, annoyance and
                      pitch affect cross-frequency interaction both within and
                      between nodes of the tinnitus network. Results of this study
                      provide, to our knowledge, the first evidence that in
                      tinnitus patients, aside from the previously described
                      changes of oscillatory activity, there are also changes of
                      cross-frequency coupling (CFC); phase-amplitude CFC was
                      increased in tinnitus patients within the auditory cortex
                      and the dorsolateral prefrontal regions between the phase of
                      delta-theta and the amplitude of gamma oscillations
                      (Modulation Index [MI] 0.17 in tinnitus patients vs. 0.08 in
                      tinnitus free controls). Moreover, theta phase in the
                      anterior cingulate region modulated gamma in the auditory
                      (MI 0.1) and dorsolateral prefrontal regions (MI 0.19).
                      Reduction of tinnitus severity after acoustic coordinated
                      reset therapy led to a partial normalization of abnormal
                      CFC. Also treatment induced changes in tinnitus pitch
                      significantly modulated changes in CFC. Thus, tinnitus
                      perception is associated with a more pronounced CFC within
                      and between nodes of the tinnitus network. CFC can
                      coordinate tinnitus-relevant activity in the tinnitus
                      network providing a mechanism for effective communication
                      between nodes of this network.Keywords: tinnitus pitch,
                      oscillations, delta band activity, alpha rhythm, gamma band
                      activity, coordinated reset neuromodulation, cross frequency
                      coupling},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333)},
      pid          = {G:(DE-HGF)POF2-333},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000346533300001},
      pubmed       = {pmid:25309309},
      doi          = {10.3389/fnins.2014.00284},
      url          = {https://juser.fz-juelich.de/record/187655},
}