000187770 001__ 187770
000187770 005__ 20210129215102.0
000187770 0247_ $$2doi$$a10.1002/hbm.22748
000187770 0247_ $$2pmid$$apmid:25627959
000187770 0247_ $$2ISSN$$a1065-9471
000187770 0247_ $$2ISSN$$a1097-0193
000187770 0247_ $$2WOS$$aWOS:000353068300023
000187770 0247_ $$2altmetric$$aaltmetric:3112213
000187770 037__ $$aFZJ-2015-01352
000187770 041__ $$aENG
000187770 082__ $$a610
000187770 1001_ $$0P:(DE-HGF)0$$aNew, Anneliese B.$$b0$$eCorresponding Author
000187770 245__ $$aThe intrinsic resting state voice network in Parkinson's disease.
000187770 260__ $$aNew York, NY$$bWiley-Liss$$c2015
000187770 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1429258265_23230
000187770 3367_ $$2DataCite$$aOutput Types/Journal article
000187770 3367_ $$00$$2EndNote$$aJournal Article
000187770 3367_ $$2BibTeX$$aARTICLE
000187770 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000187770 3367_ $$2DRIVER$$aarticle
000187770 520__ $$aOver 90 percent of patients with Parkinson's disease experience speech-motor impairment, namely, hypokinetic dysarthria characterized by reduced pitch and loudness. Resting-state functional connectivity analysis of blood oxygen level-dependent functional magnetic resonance imaging is a useful measure of intrinsic neural functioning. We utilized resting-state functional connectivity modeling to analyze the intrinsic connectivity in patients with Parkinson's disease within a vocalization network defined by a previous meta-analysis of speech (Brown et al., 2009). Functional connectivity of this network was assessed in 56 patients with Parkinson's disease and 56 gender-, age-, and movement-matched healthy controls. We also had item 5 and 18 of the UPDRS, and the PDQ-39 Communication subscale available for correlation with the voice network connectivity strength in patients. The within-group analyses of connectivity patterns demonstrated a lack of subcortical–cortical connectivity in patients with Parkinson's disease. At the cortical level, we found robust (homotopic) interhemispheric connectivity but only inconsistent evidence for many intrahemispheric connections. When directly contrasted to the control group, we found a significant reduction of connections between the left thalamus and putamen, and cortical motor areas, as well as reduced right superior temporal gyrus connectivity. Furthermore, most symptom measures correlated with right putamen, left cerebellum, left superior temporal gyrus, right premotor, and left Rolandic operculum connectivity in the voice network. The results reflect the importance of (right) subcortical nodes and the superior temporal gyrus in Parkinson's disease, enhancing our understanding of the neurobiological underpinnings of vocalization impairment in Parkinson's disease
000187770 536__ $$0G:(DE-HGF)POF3-571$$a571 - Connectivity and Activity (POF3-571)$$cPOF3-571$$fPOF III$$x0
000187770 588__ $$aDataset connected to CrossRef, juser.fz-juelich.de, PubMed,
000187770 7001_ $$0P:(DE-HGF)0$$aRobin, Donald A$$b1$$eCorresponding Author
000187770 7001_ $$0P:(DE-HGF)0$$aParkinson, Amy L$$b2
000187770 7001_ $$0P:(DE-HGF)0$$aEickhoff, Claudia R$$b3
000187770 7001_ $$0P:(DE-Juel1)162203$$aReetz, Kathrin$$b4
000187770 7001_ $$0P:(DE-Juel1)131684$$aHoffstaedter, Felix$$b5
000187770 7001_ $$0P:(DE-HGF)0$$aMathys, Christian$$b6
000187770 7001_ $$0P:(DE-HGF)0$$aSüdmeyer, Martin$$b7
000187770 7001_ $$0P:(DE-Juel1)161406$$aGrefkes, Christian$$b8
000187770 7001_ $$0P:(DE-HGF)0$$aLarson, Charles R$$b9
000187770 7001_ $$0P:(DE-HGF)0$$aRamig, Loraine O$$b10
000187770 7001_ $$0P:(DE-HGF)0$$aFox, Peter T$$b11
000187770 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon$$b12
000187770 773__ $$0PERI:(DE-600)1492703-2$$a10.1002/hbm.22748$$gp. n/a - n/a$$n5$$p1951–1962$$tHuman brain mapping$$v36$$x1065-9471$$y2015
000187770 8564_ $$uhttps://juser.fz-juelich.de/record/187770/files/hbm22748.pdf$$yRestricted
000187770 8564_ $$uhttps://juser.fz-juelich.de/record/187770/files/hbm22748.gif?subformat=icon$$xicon$$yRestricted
000187770 8564_ $$uhttps://juser.fz-juelich.de/record/187770/files/hbm22748.jpg?subformat=icon-1440$$xicon-1440$$yRestricted
000187770 8564_ $$uhttps://juser.fz-juelich.de/record/187770/files/hbm22748.jpg?subformat=icon-180$$xicon-180$$yRestricted
000187770 8564_ $$uhttps://juser.fz-juelich.de/record/187770/files/hbm22748.jpg?subformat=icon-640$$xicon-640$$yRestricted
000187770 8564_ $$uhttps://juser.fz-juelich.de/record/187770/files/hbm22748.pdf?subformat=pdfa$$xpdfa$$yRestricted
000187770 909CO $$ooai:juser.fz-juelich.de:187770$$pVDB
000187770 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)162203$$aForschungszentrum Jülich GmbH$$b4$$kFZJ
000187770 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131684$$aForschungszentrum Jülich GmbH$$b5$$kFZJ
000187770 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)161406$$aForschungszentrum Jülich GmbH$$b8$$kFZJ
000187770 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131678$$aForschungszentrum Jülich GmbH$$b12$$kFZJ
000187770 9130_ $$0G:(DE-HGF)POF2-333$$1G:(DE-HGF)POF2-330$$2G:(DE-HGF)POF2-300$$aDE-HGF$$bGesundheit$$lFunktion und Dysfunktion des Nervensystems$$vPathophysiological Mechanisms of Neurological and Psychiatric Diseases$$x0
000187770 9131_ $$0G:(DE-HGF)POF3-571$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vConnectivity and Activity$$x0
000187770 9141_ $$y2015
000187770 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR
000187770 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000187770 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000187770 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000187770 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000187770 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000187770 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000187770 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000187770 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000187770 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000187770 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000187770 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5
000187770 9201_ $$0I:(DE-Juel1)INM-1-20090406$$kINM-1$$lStrukturelle und funktionelle Organisation des Gehirns$$x0
000187770 9201_ $$0I:(DE-Juel1)INM-4-20090406$$kINM-4$$lPhysik der Medizinischen Bildgebung$$x1
000187770 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x2
000187770 980__ $$ajournal
000187770 980__ $$aVDB
000187770 980__ $$aI:(DE-Juel1)INM-1-20090406
000187770 980__ $$aI:(DE-Juel1)INM-4-20090406
000187770 980__ $$aI:(DE-Juel1)INM-3-20090406
000187770 980__ $$aUNRESTRICTED
000187770 981__ $$aI:(DE-Juel1)INM-4-20090406
000187770 981__ $$aI:(DE-Juel1)INM-3-20090406