001     187770
005     20210129215102.0
024 7 _ |a 10.1002/hbm.22748
|2 doi
024 7 _ |a pmid:25627959
|2 pmid
024 7 _ |a 1065-9471
|2 ISSN
024 7 _ |a 1097-0193
|2 ISSN
024 7 _ |a WOS:000353068300023
|2 WOS
024 7 _ |a altmetric:3112213
|2 altmetric
037 _ _ |a FZJ-2015-01352
041 _ _ |a ENG
082 _ _ |a 610
100 1 _ |a New, Anneliese B.
|0 P:(DE-HGF)0
|b 0
|e Corresponding Author
245 _ _ |a The intrinsic resting state voice network in Parkinson's disease.
260 _ _ |a New York, NY
|c 2015
|b Wiley-Liss
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1429258265_23230
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
520 _ _ |a Over 90 percent of patients with Parkinson's disease experience speech-motor impairment, namely, hypokinetic dysarthria characterized by reduced pitch and loudness. Resting-state functional connectivity analysis of blood oxygen level-dependent functional magnetic resonance imaging is a useful measure of intrinsic neural functioning. We utilized resting-state functional connectivity modeling to analyze the intrinsic connectivity in patients with Parkinson's disease within a vocalization network defined by a previous meta-analysis of speech (Brown et al., 2009). Functional connectivity of this network was assessed in 56 patients with Parkinson's disease and 56 gender-, age-, and movement-matched healthy controls. We also had item 5 and 18 of the UPDRS, and the PDQ-39 Communication subscale available for correlation with the voice network connectivity strength in patients. The within-group analyses of connectivity patterns demonstrated a lack of subcortical–cortical connectivity in patients with Parkinson's disease. At the cortical level, we found robust (homotopic) interhemispheric connectivity but only inconsistent evidence for many intrahemispheric connections. When directly contrasted to the control group, we found a significant reduction of connections between the left thalamus and putamen, and cortical motor areas, as well as reduced right superior temporal gyrus connectivity. Furthermore, most symptom measures correlated with right putamen, left cerebellum, left superior temporal gyrus, right premotor, and left Rolandic operculum connectivity in the voice network. The results reflect the importance of (right) subcortical nodes and the superior temporal gyrus in Parkinson's disease, enhancing our understanding of the neurobiological underpinnings of vocalization impairment in Parkinson's disease
536 _ _ |a 571 - Connectivity and Activity (POF3-571)
|0 G:(DE-HGF)POF3-571
|c POF3-571
|x 0
|f POF III
588 _ _ |a Dataset connected to CrossRef, juser.fz-juelich.de, PubMed,
700 1 _ |a Robin, Donald A
|0 P:(DE-HGF)0
|b 1
|e Corresponding Author
700 1 _ |a Parkinson, Amy L
|0 P:(DE-HGF)0
|b 2
700 1 _ |a Eickhoff, Claudia R
|0 P:(DE-HGF)0
|b 3
700 1 _ |a Reetz, Kathrin
|0 P:(DE-Juel1)162203
|b 4
700 1 _ |a Hoffstaedter, Felix
|0 P:(DE-Juel1)131684
|b 5
700 1 _ |a Mathys, Christian
|0 P:(DE-HGF)0
|b 6
700 1 _ |a Südmeyer, Martin
|0 P:(DE-HGF)0
|b 7
700 1 _ |a Grefkes, Christian
|0 P:(DE-Juel1)161406
|b 8
700 1 _ |a Larson, Charles R
|0 P:(DE-HGF)0
|b 9
700 1 _ |a Ramig, Loraine O
|0 P:(DE-HGF)0
|b 10
700 1 _ |a Fox, Peter T
|0 P:(DE-HGF)0
|b 11
700 1 _ |a Eickhoff, Simon
|0 P:(DE-Juel1)131678
|b 12
773 _ _ |a 10.1002/hbm.22748
|g p. n/a - n/a
|0 PERI:(DE-600)1492703-2
|n 5
|p 1951–1962
|t Human brain mapping
|v 36
|y 2015
|x 1065-9471
856 4 _ |u https://juser.fz-juelich.de/record/187770/files/hbm22748.pdf
|y Restricted
856 4 _ |u https://juser.fz-juelich.de/record/187770/files/hbm22748.gif?subformat=icon
|x icon
|y Restricted
856 4 _ |u https://juser.fz-juelich.de/record/187770/files/hbm22748.jpg?subformat=icon-1440
|x icon-1440
|y Restricted
856 4 _ |u https://juser.fz-juelich.de/record/187770/files/hbm22748.jpg?subformat=icon-180
|x icon-180
|y Restricted
856 4 _ |u https://juser.fz-juelich.de/record/187770/files/hbm22748.jpg?subformat=icon-640
|x icon-640
|y Restricted
856 4 _ |u https://juser.fz-juelich.de/record/187770/files/hbm22748.pdf?subformat=pdfa
|x pdfa
|y Restricted
909 C O |o oai:juser.fz-juelich.de:187770
|p VDB
910 1 _ |a Forschungszentrum Jülich GmbH
|0 I:(DE-588b)5008462-8
|k FZJ
|b 4
|6 P:(DE-Juel1)162203
910 1 _ |a Forschungszentrum Jülich GmbH
|0 I:(DE-588b)5008462-8
|k FZJ
|b 5
|6 P:(DE-Juel1)131684
910 1 _ |a Forschungszentrum Jülich GmbH
|0 I:(DE-588b)5008462-8
|k FZJ
|b 8
|6 P:(DE-Juel1)161406
910 1 _ |a Forschungszentrum Jülich GmbH
|0 I:(DE-588b)5008462-8
|k FZJ
|b 12
|6 P:(DE-Juel1)131678
913 0 _ |a DE-HGF
|b Gesundheit
|l Funktion und Dysfunktion des Nervensystems
|1 G:(DE-HGF)POF2-330
|0 G:(DE-HGF)POF2-333
|2 G:(DE-HGF)POF2-300
|v Pathophysiological Mechanisms of Neurological and Psychiatric Diseases
|x 0
913 1 _ |a DE-HGF
|b Key Technologies
|l Decoding the Human Brain
|1 G:(DE-HGF)POF3-570
|0 G:(DE-HGF)POF3-571
|2 G:(DE-HGF)POF3-500
|v Connectivity and Activity
|x 0
|4 G:(DE-HGF)POF
|3 G:(DE-HGF)POF3
914 1 _ |y 2015
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
915 _ _ |a WoS
|0 StatID:(DE-HGF)0110
|2 StatID
|b Science Citation Index
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Thomson Reuters Master Journal List
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
915 _ _ |a IF >= 5
|0 StatID:(DE-HGF)9905
|2 StatID
920 1 _ |0 I:(DE-Juel1)INM-1-20090406
|k INM-1
|l Strukturelle und funktionelle Organisation des Gehirns
|x 0
920 1 _ |0 I:(DE-Juel1)INM-4-20090406
|k INM-4
|l Physik der Medizinischen Bildgebung
|x 1
920 1 _ |0 I:(DE-Juel1)INM-3-20090406
|k INM-3
|l Kognitive Neurowissenschaften
|x 2
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-Juel1)INM-1-20090406
980 _ _ |a I:(DE-Juel1)INM-4-20090406
980 _ _ |a I:(DE-Juel1)INM-3-20090406
980 _ _ |a UNRESTRICTED
981 _ _ |a I:(DE-Juel1)INM-4-20090406
981 _ _ |a I:(DE-Juel1)INM-3-20090406


LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21