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000188029 041__ $$aEnglish
000188029 1001_ $$0P:(DE-Juel1)133346$$aSchmitz, Sabine$$b0$$eCorresponding Author$$ufzj
000188029 1112_ $$a17. Annual Meeting of the Society for Biological Radiation Research$$cTübingen$$d2014-09-29 - 2014-10-01$$gGBS$$wGermany
000188029 245__ $$aAnalysis of Iodine-125-induced chromosome aberrations
000188029 260__ $$c2014
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000188029 520__ $$aDNA-associated Auger-electron emitters (AEE) induce cellular damage leading to high-LET type cell survival curves and possess enhanced relative biological effectiveness. Moreover, DNA dsb induced by 125I-deoxyuridine (125I-UdR) decays are claimed to be very complex. To elucidate the assumed genotoxic potential, chromosome aberrations were analyzed in 125I-UdR-exposed human peripheral blood lymphocytes (PBL).After 18 h labeling with 125I-UdR the cell cycle distribution is severely disturbed. Furthermore, 40% of PBL are fully labelled and 20% show a moderate uptake. Primarily chromatid-type aberrations are induced. PBL reveal a very broad dose-dependent response spectrum: equal numbers of cells have either no aberration, or display a moderate aberration level. Few cells exhibit a high aberration score (> 10 aberrations). A dose-dependent increase of aberrations is measured in the range of 0.2 to 2 Gy, followed by a plateau between 2 and 4.5 Gy. The data indicate that even the lowest dose of 0.2 Gy leads to a 4.5-fold increase of aberrations in PBL compared to the controls. Furthermore, a dose-dependent increase of cell death is observed.125I-UdR has a very strong genotoxic capacity in human PBL even at very low doses of about 0.2 Gy. Efficiently labeled cells display a prolonged cell cycle compared to moderate labeled cells and cell death contributes substantially to the desynchronisation of the cell cycle. It can be concluded that every fourth intracellular 125I decay give rise to a single chromosome aberration.
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000188029 7001_ $$0P:(DE-Juel1)133339$$aOskamp, Dominik$$b1$$ufzj
000188029 7001_ $$0P:(DE-Juel1)133341$$aPomplun, Ekkehard$$b2$$ufzj
000188029 7001_ $$0P:(DE-Juel1)133469$$aKriehuber, Ralf$$b3$$ufzj
000188029 773__ $$y2014
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