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@INPROCEEDINGS{Schmitz:188029,
      author       = {Schmitz, Sabine and Oskamp, Dominik and Pomplun, Ekkehard
                      and Kriehuber, Ralf},
      title        = {{A}nalysis of {I}odine-125-induced chromosome aberrations},
      reportid     = {FZJ-2015-01514},
      year         = {2014},
      abstract     = {DNA-associated Auger-electron emitters (AEE) induce
                      cellular damage leading to high-LET type cell survival
                      curves and possess enhanced relative biological
                      effectiveness. Moreover, DNA dsb induced by
                      125I-deoxyuridine (125I-UdR) decays are claimed to be very
                      complex. To elucidate the assumed genotoxic potential,
                      chromosome aberrations were analyzed in 125I-UdR-exposed
                      human peripheral blood lymphocytes (PBL).After 18 h labeling
                      with 125I-UdR the cell cycle distribution is severely
                      disturbed. Furthermore, $40\%$ of PBL are fully labelled and
                      $20\%$ show a moderate uptake. Primarily chromatid-type
                      aberrations are induced. PBL reveal a very broad
                      dose-dependent response spectrum: equal numbers of cells
                      have either no aberration, or display a moderate aberration
                      level. Few cells exhibit a high aberration score (> 10
                      aberrations). A dose-dependent increase of aberrations is
                      measured in the range of 0.2 to 2 Gy, followed by a plateau
                      between 2 and 4.5 Gy. The data indicate that even the lowest
                      dose of 0.2 Gy leads to a 4.5-fold increase of aberrations
                      in PBL compared to the controls. Furthermore, a
                      dose-dependent increase of cell death is observed.125I-UdR
                      has a very strong genotoxic capacity in human PBL even at
                      very low doses of about 0.2 Gy. Efficiently labeled cells
                      display a prolonged cell cycle compared to moderate labeled
                      cells and cell death contributes substantially to the
                      desynchronisation of the cell cycle. It can be concluded
                      that every fourth intracellular 125I decay give rise to a
                      single chromosome aberration.},
      month         = {Sep},
      date          = {2014-09-29},
      organization  = {17. Annual Meeting of the Society for
                       Biological Radiation Research,
                       Tübingen (Germany), 29 Sep 2014 - 1
                       Oct 2014},
      subtyp        = {After Call},
      cin          = {S-US},
      cid          = {I:(DE-Juel1)S-US-20090406},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      typ          = {PUB:(DE-HGF)24},
      url          = {https://juser.fz-juelich.de/record/188029},
}