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@ARTICLE{Dayan:188297,
      author       = {Dayan, Michael and Kreutzer, Sylvia and Clark, Chris A.},
      title        = {{T}ractography of the optic radiation: a repeatability and
                      reproducibility study},
      journal      = {NMR in biomedicine},
      volume       = {28},
      number       = {4},
      issn         = {0952-3480},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {FZJ-2015-01719},
      pages        = {423–431},
      year         = {2015},
      abstract     = {Our main objective was to evaluate the repeatability and
                      reproducibility of optic radiation (OR) reconstruction from
                      diffusion MRI (dMRI) data. 14 adults were scanned twice with
                      the same 60-direction dMRI sequence. Peaks in the diffusion
                      profile were estimated with the single tensor (ST), Q-ball
                      (QSH) and persistent angular structure (PAS) methods.
                      Segmentation of the OR was performed by two experimenters
                      with probabilistic tractography based on a manually drawn
                      region-of-interest (ROI) protocol typically employed for OR
                      segmentation, with both standard and extended sets of ROIs.
                      The repeatability and reproducibility were assessed by
                      calculating the intra-class correlation coefficient (ICC) of
                      intra- and inter-rater experiments, respectively. ICCs were
                      calculated for commonly used dMRI metrics (FA, MD, AD, RD)
                      and anatomical dimensions of the optic radiation (distance
                      from Meyer's loop to the temporal pole, ML-TP), as well as
                      the Dice similarity coefficient (DSC) between the raters’
                      OR segmentation. Bland–Altman plots were also calculated
                      to investigate bias and variability in the reproducibility
                      measurements.The OR was successfully reconstructed in all
                      subjects by both raters. The ICC was found to be in the good
                      to excellent range for both repeatability and
                      reproducibility of the dMRI metrics, DSC and ML-TP distance.
                      The Bland–Altman plots did not show any apparent
                      systematic bias for any quantities.Overall, higher ICC
                      values were found for the multi-fiber methods, QSH and PAS,
                      and for the standard set of ROIs. Considering the good to
                      excellent repeatability and reproducibility of all the
                      quantities investigated, these findings support the use of
                      multi-fiber OR reconstruction with a limited number of
                      manually drawn ROIs in clinical applications utilizing
                      either OR microstructure characterization or OR dimensions,
                      as is the case in neurosurgical planning for temporal
                      lobectomy},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000351474500001},
      doi          = {10.1002/nbm.3266},
      url          = {https://juser.fz-juelich.de/record/188297},
}