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@ARTICLE{Buescher:188342,
author = {Buescher, Joerg M and Antoniewicz, Maciek R and Boros,
Laszlo G and Burgess, Shawn C and Brunengraber, Henri and
Clish, Clary B and DeBerardinis, Ralph J and Feron, Olivier
and Frezza, Christian and Ghesquiere, Bart and Gottlieb,
Eyal and Hiller, Karsten and Jones, Russell G and Kamphorst,
Jurre J and Kibbey, Richard G and Kimmelman, Alec C and
Locasale, Jason W and Lunt, Sophia Y and Maddocks, Oliver DK
and Malloy, Craig and Metallo, Christian M and Meuillet,
Emmanuelle J and Munger, Joshua and Nöh, Katharina and
Rabinowitz, Joshua D and Ralser, Markus and Sauer, Uwe and
Stephanopoulos, Gregory and St-Pierre, Julie and Tennant,
Daniel A and Wittmann, Christoph and Vander Heiden, Matthew
G and Vazquez, Alexei and Vousden, Karen and Young, Jamey D
and Zamboni, Nicola and Fendt, Sarah-Maria},
title = {{A} roadmap for interpreting 13{C} metabolite labeling
patterns from cells},
journal = {Current opinion in biotechnology},
volume = {34},
issn = {0958-1669},
address = {Amsterdam [u.a.]},
publisher = {Elsevier Science},
reportid = {FZJ-2015-01750},
pages = {189 - 201},
year = {2015},
abstract = {Measuring intracellular metabolism has increasingly led to
important insights in biomedical research. 13C tracer
analysis, although less information-rich than quantitative
13C flux analysis that requires computational data
integration, has been established as a time-efficient method
to unravel relative pathway activities, qualitative changes
in pathway contributions, and nutrient contributions. Here,
we review selected key issues in interpreting 13C metabolite
labeling patterns, with the goal of drawing accurate
conclusions from steady state and dynamic stable isotopic
tracer experiments.},
cin = {IBG-1},
ddc = {610},
cid = {I:(DE-Juel1)IBG-1-20101118},
pnm = {581 - Biotechnology (POF3-581)},
pid = {G:(DE-HGF)POF3-581},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000361256300026},
pubmed = {pmid:25731751},
doi = {10.1016/j.copbio.2015.02.003},
url = {https://juser.fz-juelich.de/record/188342},
}