000188458 001__ 188458
000188458 005__ 20240619091131.0
000188458 0247_ $$2doi$$a10.1107/S2053230X14004087
000188458 0247_ $$2WOS$$aWOS:000333757800014
000188458 0247_ $$2altmetric$$aaltmetric:2212845
000188458 0247_ $$2pmid$$apmid:24699741
000188458 037__ $$aFZJ-2015-01834
000188458 082__ $$a530
000188458 1001_ $$0P:(DE-HGF)0$$aYokoyama, Takeshi$$b0$$eCorresponding Author
000188458 245__ $$aCrystallization and preliminary neutron diffraction experiment of human farnesyl pyrophosphate synthase complexed with risedronate
000188458 260__ $$aOxford [u.a.]$$bBlackwell$$c2014
000188458 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1426157276_7587
000188458 3367_ $$2DataCite$$aOutput Types/Journal article
000188458 3367_ $$00$$2EndNote$$aJournal Article
000188458 3367_ $$2BibTeX$$aARTICLE
000188458 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000188458 3367_ $$2DRIVER$$aarticle
000188458 520__ $$aNitrogen-containing bisphosphonates (N-BPs), such as risedronate and zoledronate, are currently used as a clinical drug for bone-resorption diseases and are potent inhibitors of farnesyl pyrophosphate synthase (FPPS). X-ray crystallographic analyses of FPPS with N-BPs have revealed that N-BPs bind to FPPS with three magnesium ions and several water molecules. To understand the structural characteristics of N-BPs bound to FPPS, including H atoms and hydration by water, neutron diffraction studies were initiated using BIODIFF at the Heinz Maier-Leibnitz Zentrum (MLZ). FPPS-risedronate complex crystals of approximate dimensions 2.8 × 2.5 × 1.5 mm (~3.5 mm3) were obtained by repeated macro-seeding. Monochromatic neutron diffraction data were collected to 2.4 Å resolution with 98.4% overall completeness. Here, the first successful neutron data collection from FPPS in complex with N-BPs is reported.
000188458 536__ $$0G:(DE-HGF)POF2-54G24$$a54G - JCNS (POF2-54G24)$$cPOF2-54G24$$fPOF II$$x0
000188458 588__ $$aDataset connected to CrossRef, juser.fz-juelich.de
000188458 65027 $$0V:(DE-MLZ)SciArea-160$$2V:(DE-HGF)$$aBiology$$x0
000188458 65017 $$0V:(DE-MLZ)GC-130-2016$$2V:(DE-HGF)$$aHealth and Life$$x2
000188458 65017 $$0V:(DE-MLZ)GC-130-1$$2V:(DE-HGF)$$aHealth and Life$$x1
000188458 65017 $$0V:(DE-MLZ)GC-130$$2V:(DE-HGF)$$aLife Science and Health$$x0
000188458 693__ $$0EXP:(DE-MLZ)BIODIFF-20140101$$1EXP:(DE-MLZ)FRMII-20140101$$5EXP:(DE-MLZ)BIODIFF-20140101$$6EXP:(DE-MLZ)NL1-20140101$$aForschungs-Neutronenquelle Heinz Maier-Leibnitz $$eBIODIFF: Diffractometer for large unit cells$$fNL1$$x0
000188458 7001_ $$0P:(DE-HGF)0$$aOstermann, Andreas$$b1
000188458 7001_ $$0P:(DE-HGF)0$$aMizuguchi, Mineyuki$$b2
000188458 7001_ $$0P:(DE-HGF)0$$aNiimura, Nobuo$$b3
000188458 7001_ $$0P:(DE-Juel1)138266$$aSchrader, Tobias E.$$b4$$ufzj
000188458 7001_ $$0P:(DE-HGF)0$$aTanaka, Ichiro$$b5
000188458 773__ $$0PERI:(DE-600)2175956-X$$a10.1107/S2053230X14004087$$p470$$tActa crystallographica / F$$v70$$x1744-3091$$y2014
000188458 909CO $$ooai:juser.fz-juelich.de:188458$$pVDB$$pVDB:MLZ
000188458 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)138266$$aForschungszentrum Jülich GmbH$$b4$$kFZJ
000188458 9132_ $$0G:(DE-HGF)POF3-600$$1G:(DE-HGF)POF3$$2G:(DE-HGF)POF$$9G:(DE-HGF)POF3-6G15$$aDE-HGF$$bProgrammorientierte Förderung$$lPOF III$$vForschungsbereich Materie$$x0
000188458 9132_ $$0G:(DE-HGF)POF3-623$$1G:(DE-HGF)POF3-620$$2G:(DE-HGF)POF3-600$$9G:(DE-HGF)POF3-6G4$$aDE-HGF$$bForschungsbereich Materie$$lVon Materie zu Materialien und Leben$$vFacility topic: Neutrons for Research on Condensed Matter$$x1
000188458 9131_ $$0G:(DE-HGF)POF2-54G24$$1G:(DE-HGF)POF2-540$$2G:(DE-HGF)POF2-500$$3G:(DE-HGF)POF2$$4G:(DE-HGF)POF$$aDE-HGF$$bStruktur der Materie$$lForschung mit Photonen, Neutronen, Ionen$$vJCNS$$x0
000188458 9141_ $$y2014
000188458 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR
000188458 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000188458 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000188458 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000188458 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000188458 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000188458 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000188458 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000188458 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF <  5
000188458 920__ $$lyes
000188458 9201_ $$0I:(DE-Juel1)JCNS-FRM-II-20110218$$kJCNS (München) ; Jülich Centre for Neutron Science JCNS (München) ; JCNS-FRM-II$$lJCNS-FRM-II$$x0
000188458 9201_ $$0I:(DE-Juel1)JCNS-1-20110106$$kNeutronenstreuung ; JCNS-1$$lNeutronenstreuung $$x1
000188458 980__ $$ajournal
000188458 980__ $$aVDB
000188458 980__ $$aI:(DE-Juel1)JCNS-FRM-II-20110218
000188458 980__ $$aI:(DE-Juel1)JCNS-1-20110106
000188458 980__ $$aUNRESTRICTED