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@ARTICLE{Yokoyama:188458,
      author       = {Yokoyama, Takeshi and Ostermann, Andreas and Mizuguchi,
                      Mineyuki and Niimura, Nobuo and Schrader, Tobias E. and
                      Tanaka, Ichiro},
      title        = {{C}rystallization and preliminary neutron diffraction
                      experiment of human farnesyl pyrophosphate synthase
                      complexed with risedronate},
      journal      = {Acta crystallographica / F},
      volume       = {70},
      issn         = {1744-3091},
      address      = {Oxford [u.a.]},
      publisher    = {Blackwell},
      reportid     = {FZJ-2015-01834},
      pages        = {470},
      year         = {2014},
      abstract     = {Nitrogen-containing bisphosphonates (N-BPs), such as
                      risedronate and zoledronate, are currently used as a
                      clinical drug for bone-resorption diseases and are potent
                      inhibitors of farnesyl pyrophosphate synthase (FPPS). X-ray
                      crystallographic analyses of FPPS with N-BPs have revealed
                      that N-BPs bind to FPPS with three magnesium ions and
                      several water molecules. To understand the structural
                      characteristics of N-BPs bound to FPPS, including H atoms
                      and hydration by water, neutron diffraction studies were
                      initiated using BIODIFF at the Heinz Maier-Leibnitz Zentrum
                      (MLZ). FPPS-risedronate complex crystals of approximate
                      dimensions 2.8 × 2.5 × 1.5 mm (~3.5 mm3) were obtained by
                      repeated macro-seeding. Monochromatic neutron diffraction
                      data were collected to 2.4 Å resolution with $98.4\%$
                      overall completeness. Here, the first successful neutron
                      data collection from FPPS in complex with N-BPs is
                      reported.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {530},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {54G - JCNS (POF2-54G24)},
      pid          = {G:(DE-HGF)POF2-54G24},
      experiment   = {EXP:(DE-MLZ)BIODIFF-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000333757800014},
      pubmed       = {pmid:24699741},
      doi          = {10.1107/S2053230X14004087},
      url          = {https://juser.fz-juelich.de/record/188458},
}