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| Hauptseite > Publikationsdatenbank > Crystallization and preliminary neutron diffraction experiment of human farnesyl pyrophosphate synthase complexed with risedronate > print |
| Hauptseite > Publikationsdatenbank > Crystallization and preliminary neutron diffraction experiment of human farnesyl pyrophosphate synthase complexed with risedronate > print |
| 001 | 188458 | ||
| 005 | 20240619091131.0 | ||
| 024 | 7 | _ | |a 10.1107/S2053230X14004087 |2 doi |
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| 024 | 7 | _ | |a altmetric:2212845 |2 altmetric |
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| 037 | _ | _ | |a FZJ-2015-01834 |
| 082 | _ | _ | |a 530 |
| 100 | 1 | _ | |a Yokoyama, Takeshi |0 P:(DE-HGF)0 |b 0 |e Corresponding Author |
| 245 | _ | _ | |a Crystallization and preliminary neutron diffraction experiment of human farnesyl pyrophosphate synthase complexed with risedronate |
| 260 | _ | _ | |a Oxford [u.a.] |c 2014 |b Blackwell |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1426157276_7587 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 520 | _ | _ | |a Nitrogen-containing bisphosphonates (N-BPs), such as risedronate and zoledronate, are currently used as a clinical drug for bone-resorption diseases and are potent inhibitors of farnesyl pyrophosphate synthase (FPPS). X-ray crystallographic analyses of FPPS with N-BPs have revealed that N-BPs bind to FPPS with three magnesium ions and several water molecules. To understand the structural characteristics of N-BPs bound to FPPS, including H atoms and hydration by water, neutron diffraction studies were initiated using BIODIFF at the Heinz Maier-Leibnitz Zentrum (MLZ). FPPS-risedronate complex crystals of approximate dimensions 2.8 × 2.5 × 1.5 mm (~3.5 mm3) were obtained by repeated macro-seeding. Monochromatic neutron diffraction data were collected to 2.4 Å resolution with 98.4% overall completeness. Here, the first successful neutron data collection from FPPS in complex with N-BPs is reported. |
| 536 | _ | _ | |a 54G - JCNS (POF2-54G24) |0 G:(DE-HGF)POF2-54G24 |c POF2-54G24 |f POF II |x 0 |
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| 693 | _ | _ | |a Forschungs-Neutronenquelle Heinz Maier-Leibnitz |e BIODIFF: Diffractometer for large unit cells |f NL1 |1 EXP:(DE-MLZ)FRMII-20140101 |0 EXP:(DE-MLZ)BIODIFF-20140101 |5 EXP:(DE-MLZ)BIODIFF-20140101 |6 EXP:(DE-MLZ)NL1-20140101 |x 0 |
| 700 | 1 | _ | |a Ostermann, Andreas |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Mizuguchi, Mineyuki |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Niimura, Nobuo |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Schrader, Tobias E. |0 P:(DE-Juel1)138266 |b 4 |u fzj |
| 700 | 1 | _ | |a Tanaka, Ichiro |0 P:(DE-HGF)0 |b 5 |
| 773 | _ | _ | |a 10.1107/S2053230X14004087 |0 PERI:(DE-600)2175956-X |p 470 |t Acta crystallographica / F |v 70 |y 2014 |x 1744-3091 |
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