000188517 001__ 188517
000188517 005__ 20240619091131.0
000188517 037__ $$aFZJ-2015-01876
000188517 041__ $$aEnglish
000188517 1001_ $$0P:(DE-Juel1)138266$$aSchrader, Tobias Erich$$b0$$eCorresponding Author$$ufzj
000188517 1112_ $$a15th International Conference on the Crystallization of Biological Macromolecules$$cHamburg$$d2014-09-17 - 2014-09-20$$gICCBM15$$wGermany
000188517 245__ $$aBioDiff - a DiffractometerOptimized for Crystals withLarge Unit Cells
000188517 260__ $$c2014
000188517 3367_ $$0PUB:(DE-HGF)6$$2PUB:(DE-HGF)$$aConference Presentation$$bconf$$mconf$$s1426170417_7587$$xPlenary/Keynote
000188517 3367_ $$033$$2EndNote$$aConference Paper
000188517 3367_ $$2DataCite$$aOther
000188517 3367_ $$2ORCID$$aLECTURE_SPEECH
000188517 3367_ $$2DRIVER$$aconferenceObject
000188517 3367_ $$2BibTeX$$aINPROCEEDINGS
000188517 520__ $$aIn recent years many new neutron protein diffractometers have become operational, e.g. Mandi at SNS, Imagine at HIFR, BioDiff at MLZ The research reactor Heinz Maier-Leibnitz (FRM II) is a modern high flux neutron source which feeds some 30 state of the art neutron beam instruments. Currently 24 are operational, others in commissioning or under construction. The newly built neutron single crystal diffractometer BIODIFF is especially designed to collect data from crystals with large unit cells. The main field of application is the structural analysis of proteins, especially the determination of hydrogen atom positions. BIODIFF is a joint project of the Jülich Centre for Neutron Science (JCNS) and the FRM II. Typical scientific questions addressed are the determination of protonation states of amino acid side chains (see e. g. [1,2]) and the characterization of the hydrogen bonding network between the protein active centre and an inhibitor or substrate. BIODIFF is designed as a monochromatic instrument. By using a highly orientated pyrolytic graphite monochromator (PG002) the diffractometer is able to operate in the wavelength range of 2.4 Å to about 5.6 Å. Contaminations of higher order wavelengths are removed by a neutron velocity selector. To cover a large solid angle the main detector of BIODIFF consists of a neutron imaging plate in a cylindrical geometry with online read-out capability. A fast Li/ZnS scintillator CCD camera is available for additional detection abilities. An optical CCD-camera pointing at the sample position is used to quickly align the crystal with respect to the neutron beam. The main advantage of BIODIFF is the possibility to adapt the wavelength to the size of the unit cell of the sample crystal while operating with a clean monochromatic beam that keeps the background level low. BIODIFF is equipped with a standard Oxford Cryosystem “Cryostream 700+” which allows measurements in the temperature regime from 90K up to 500K (see Figure underneath).
000188517 536__ $$0G:(DE-HGF)POF2-451$$a451 - Soft Matter Composites (POF2-451)$$cPOF2-451$$fPOF II$$x0
000188517 536__ $$0G:(DE-HGF)POF2-54G24$$a54G - JCNS (POF2-54G24)$$cPOF2-54G24$$fPOF II$$x1
000188517 65027 $$0V:(DE-MLZ)SciArea-220$$2V:(DE-HGF)$$aInstrument and Method Development$$x1
000188517 65027 $$0V:(DE-MLZ)SciArea-160$$2V:(DE-HGF)$$aBiology$$x0
000188517 65017 $$0V:(DE-MLZ)GC-2002-2016$$2V:(DE-HGF)$$aInstrument and Method Development$$x2
000188517 65017 $$0V:(DE-MLZ)GC-180$$2V:(DE-HGF)$$aOthers$$x1
000188517 65017 $$0V:(DE-MLZ)GC-130$$2V:(DE-HGF)$$aLife Science and Health$$x0
000188517 693__ $$0EXP:(DE-MLZ)BIODIFF-20140101$$1EXP:(DE-MLZ)FRMII-20140101$$5EXP:(DE-MLZ)BIODIFF-20140101$$6EXP:(DE-MLZ)NL1-20140101$$aForschungs-Neutronenquelle Heinz Maier-Leibnitz $$eBIODIFF: Diffractometer for large unit cells$$fNL1$$x0
000188517 773__ $$y2014
000188517 8564_ $$uhttp://www.iccbm15.org/iccbm15.xhtml
000188517 8564_ $$uhttps://juser.fz-juelich.de/record/188517/files/FZJ-2015-01876.pdf$$yRestricted
000188517 909CO $$ooai:juser.fz-juelich.de:188517$$pVDB$$pVDB:MLZ
000188517 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)138266$$aForschungszentrum Jülich GmbH$$b0$$kFZJ
000188517 9132_ $$0G:(DE-HGF)POF3-621$$1G:(DE-HGF)POF3-620$$2G:(DE-HGF)POF3-600$$9G:(DE-HGF)POF3-6215$$aDE-HGF$$bForschungsbereich Materie$$lVon Materie zu Materialien und Leben$$vIn-house research on the structure, dynamics and function of matter$$x0
000188517 9132_ $$0G:(DE-HGF)POF3-600$$1G:(DE-HGF)POF3$$2G:(DE-HGF)POF$$9G:(DE-HGF)POF3-6G15$$aDE-HGF$$bProgrammorientierte Förderung$$lPOF III$$vForschungsbereich Materie$$x1
000188517 9132_ $$0G:(DE-HGF)POF3-623$$1G:(DE-HGF)POF3-620$$2G:(DE-HGF)POF3-600$$9G:(DE-HGF)POF3-6G4$$aDE-HGF$$bForschungsbereich Materie$$lVon Materie zu Materialien und Leben$$vFacility topic: Neutrons for Research on Condensed Matter$$x2
000188517 9131_ $$0G:(DE-HGF)POF2-451$$1G:(DE-HGF)POF2-450$$2G:(DE-HGF)POF2-400$$3G:(DE-HGF)POF2$$4G:(DE-HGF)POF$$aDE-HGF$$bSchlüsseltechnologien$$lBioSoft$$vSoft Matter Composites$$x0
000188517 9131_ $$0G:(DE-HGF)POF2-54G24$$1G:(DE-HGF)POF2-540$$2G:(DE-HGF)POF2-500$$3G:(DE-HGF)POF2$$4G:(DE-HGF)POF$$aDE-HGF$$bStruktur der Materie$$lForschung mit Photonen, Neutronen, Ionen$$vJCNS$$x1
000188517 9141_ $$y2014
000188517 920__ $$lyes
000188517 9201_ $$0I:(DE-Juel1)JCNS-FRM-II-20110218$$kJCNS (München) ; Jülich Centre for Neutron Science JCNS (München) ; JCNS-FRM-II$$lJCNS-FRM-II$$x0
000188517 9201_ $$0I:(DE-Juel1)JCNS-1-20110106$$kNeutronenstreuung ; JCNS-1$$lNeutronenstreuung $$x1
000188517 980__ $$aconf
000188517 980__ $$aVDB
000188517 980__ $$aI:(DE-Juel1)JCNS-FRM-II-20110218
000188517 980__ $$aI:(DE-Juel1)JCNS-1-20110106
000188517 980__ $$aUNRESTRICTED