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@INPROCEEDINGS{Schrader:188517,
      author       = {Schrader, Tobias Erich},
      title        = {{B}io{D}iff - a {D}iffractometer{O}ptimized for {C}rystals
                      with{L}arge {U}nit {C}ells},
      reportid     = {FZJ-2015-01876},
      year         = {2014},
      abstract     = {In recent years many new neutron protein diffractometers
                      have become operational, e.g. Mandi at SNS, Imagine at HIFR,
                      BioDiff at MLZ The research reactor Heinz Maier-Leibnitz
                      (FRM II) is a modern high flux neutron source which feeds
                      some 30 state of the art neutron beam instruments. Currently
                      24 are operational, others in commissioning or under
                      construction. The newly built neutron single crystal
                      diffractometer BIODIFF is especially designed to collect
                      data from crystals with large unit cells. The main field of
                      application is the structural analysis of proteins,
                      especially the determination of hydrogen atom positions.
                      BIODIFF is a joint project of the Jülich Centre for Neutron
                      Science (JCNS) and the FRM II. Typical scientific questions
                      addressed are the determination of protonation states of
                      amino acid side chains (see e. g. [1,2]) and the
                      characterization of the hydrogen bonding network between the
                      protein active centre and an inhibitor or substrate. BIODIFF
                      is designed as a monochromatic instrument. By using a highly
                      orientated pyrolytic graphite monochromator (PG002) the
                      diffractometer is able to operate in the wavelength range of
                      2.4 Å to about 5.6 Å. Contaminations of higher order
                      wavelengths are removed by a neutron velocity selector. To
                      cover a large solid angle the main detector of BIODIFF
                      consists of a neutron imaging plate in a cylindrical
                      geometry with online read-out capability. A fast Li/ZnS
                      scintillator CCD camera is available for additional
                      detection abilities. An optical CCD-camera pointing at the
                      sample position is used to quickly align the crystal with
                      respect to the neutron beam. The main advantage of BIODIFF
                      is the possibility to adapt the wavelength to the size of
                      the unit cell of the sample crystal while operating with a
                      clean monochromatic beam that keeps the background level
                      low. BIODIFF is equipped with a standard Oxford Cryosystem
                      “Cryostream 700+” which allows measurements in the
                      temperature regime from 90K up to 500K (see Figure
                      underneath).},
      month         = {Sep},
      date          = {2014-09-17},
      organization  = {15th International Conference on the
                       Crystallization of Biological
                       Macromolecules, Hamburg (Germany), 17
                       Sep 2014 - 20 Sep 2014},
      subtyp        = {Plenary/Keynote},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {451 - Soft Matter Composites (POF2-451) / 54G - JCNS
                      (POF2-54G24)},
      pid          = {G:(DE-HGF)POF2-451 / G:(DE-HGF)POF2-54G24},
      experiment   = {EXP:(DE-MLZ)BIODIFF-20140101},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/188517},
}