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@ARTICLE{Kuhn:188612,
      author       = {Kuhn, J. and Hardenacke, K. and Lenartz, D. and Gruendler,
                      T. and Ullsperger, M. and Bartsch, C. and Mai, J. K. and
                      Zilles, K. and Bauer, Andreas and Matusch, A. and Schulz,
                      R-J and Noreik, M. and Bührle, C. P. and Maintz, D. and
                      Woopen, C. and Häussermann, P. and Hellmich, M. and
                      Klosterkötter, J. and Wiltfang, J. and Maarouf, M. and
                      Freund, Hans-Joachim and Sturm, V.},
      title        = {{D}eep brain stimulation of the nucleus basalis of
                      {M}eynert in {A}lzheimer’s dementia},
      journal      = {Molecular psychiatry},
      volume       = {20},
      number       = {3},
      issn         = {1476-5578},
      address      = {London},
      publisher    = {Macmillan},
      reportid     = {FZJ-2015-01954},
      pages        = {353 - 360},
      year         = {2015},
      abstract     = {Cholinergic neurons of the medial forebrain are considered
                      important contributors to brain plasticity and
                      neuromodulation. A reduction of cholinergic innervation can
                      lead to pathophysiological changes of neurotransmission and
                      is observed in Alzheimer’s disease. Here we report on six
                      patients with mild to moderate Alzheimer’s disease (AD)
                      treated with bilateral low-frequency deep brain stimulation
                      (DBS) of the nucleus basalis of Meynert (NBM). During a
                      four-week double-blind sham-controlled phase and a
                      subsequent 11-month follow-up open label period, clinical
                      outcome was assessed by neuropsychological examination using
                      the Alzheimer’s Disease Assessment Scale—cognitive
                      subscale as the primary outcome measure.
                      Electroencephalography and [18F]-fluoro-desoxyglucose
                      positron emission tomography were, besides others, secondary
                      endpoints. On the basis of stable or improved primary
                      outcome parameters twelve months after surgery, four of the
                      six patients were considered responders. No severe or
                      non-transitional side effects related to the stimulation
                      were observed. Taking into account all limitations of a
                      pilot study, we conclude that DBS of the NBM is both
                      technically feasible and well tolerated.},
      cin          = {INM-1 / INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000351779300009},
      pubmed       = {pmid:24798585},
      doi          = {10.1038/mp.2014.32},
      url          = {https://juser.fz-juelich.de/record/188612},
}