TY  - JOUR
AU  - Lohmann, Philipp
AU  - Herzog, Hans
AU  - Rota Kops, Elena
AU  - Stoffels, Gabriele
AU  - Judov, Natalie
AU  - Filss, Christian
AU  - Galldiks, Norbert
AU  - Tellmann, Lutz
AU  - Weiss, Carolin
AU  - Sabel, Michael
AU  - Coenen, Heinrich Hubert
AU  - Shah, N. J.
AU  - Langen, Karl-Josef
TI  - Dual-time-point O-(2-[$^{18}$F]fluoroethyl)-L-tyrosine PET  for grading of cerebral gliomas
JO  - European radiology
VL  - 25
IS  - 10
SN  - 0938-7994
CY  - Berlin
PB  - Springer
M1  - FZJ-2015-02041
SP  - 3017–3024
PY  - 2015
AB  - ObjectiveWe aimed to evaluate the diagnostic potential of dual-time-point imaging with positron emission tomography (PET) using O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET) for non-invasive grading of cerebral gliomas compared with a dynamic approach.MethodsThirty-six patients with histologically confirmed cerebral gliomas (21 primary, 15 recurrent; 24 high-grade, 12 low-grade) underwent dynamic PET from 0 to 50 min post-injection (p.i.) of 18F-FET, and additionally from 70 to 90 min p.i. Mean tumour-to-brain ratios (TBRmean) of 18F-FET uptake were determined in early (20–40 min p.i.) and late (70–90 min p.i.) examinations. Time–activity curves (TAC) of the tumours from 0 to 50 min after injection were assigned to different patterns. The diagnostic accuracy of changes of 18F-FET uptake between early and late examinations for tumour grading was compared to that of curve pattern analysis from 0 to 50 min p.i. of 18F-FET.ResultsThe diagnostic accuracy of changes of the TBRmean of 18F-FET PET uptake between early and late examinations for the identification of HGG was 81 % (sensitivity 83 %; specificity 75 %; cutoff - 8 %; p < 0.001), and 83 % for curve pattern analysis (sensitivity 88 %; specificity 75 %; p < 0.001).ConclusionDual-time-point imaging of 18F-FET uptake in gliomas achieves diagnostic accuracy for tumour grading that is similar to the more time-consuming dynamic data acquisition protocol.Key Points• Dual-time-point imaging is equivalent to dynamic FET PET for grading of gliomas.• Dual-time-point imaging is less time consuming than dynamic FET PET.• Costs can be reduced due to higher patient throughput.• Reduced imaging time increases patient comfort and sedation might be avoided.• Quicker image interpretation is possible, as no curve evaluation is necessary.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000360849200025
DO  - DOI:10.1007/s00330-015-3691-6
UR  - https://juser.fz-juelich.de/record/188717
ER  -