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@ARTICLE{Lohmann:188717,
      author       = {Lohmann, Philipp and Herzog, Hans and Rota Kops, Elena and
                      Stoffels, Gabriele and Judov, Natalie and Filss, Christian
                      and Galldiks, Norbert and Tellmann, Lutz and Weiss, Carolin
                      and Sabel, Michael and Coenen, Heinrich Hubert and Shah, N.
                      J. and Langen, Karl-Josef},
      title        = {{D}ual-time-point
                      {O}-(2-[$^{18}${F}]fluoroethyl)-{L}-tyrosine {PET} for
                      grading of cerebral gliomas},
      journal      = {European radiology},
      volume       = {25},
      number       = {10},
      issn         = {0938-7994},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {FZJ-2015-02041},
      pages        = {3017–3024},
      year         = {2015},
      abstract     = {ObjectiveWe aimed to evaluate the diagnostic potential of
                      dual-time-point imaging with positron emission tomography
                      (PET) using O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET) for
                      non-invasive grading of cerebral gliomas compared with a
                      dynamic approach.MethodsThirty-six patients with
                      histologically confirmed cerebral gliomas (21 primary, 15
                      recurrent; 24 high-grade, 12 low-grade) underwent dynamic
                      PET from 0 to 50 min post-injection (p.i.) of 18F-FET, and
                      additionally from 70 to 90 min p.i. Mean tumour-to-brain
                      ratios (TBRmean) of 18F-FET uptake were determined in early
                      (20–40 min p.i.) and late (70–90 min p.i.) examinations.
                      Time–activity curves (TAC) of the tumours from 0 to 50 min
                      after injection were assigned to different patterns. The
                      diagnostic accuracy of changes of 18F-FET uptake between
                      early and late examinations for tumour grading was compared
                      to that of curve pattern analysis from 0 to 50 min p.i. of
                      18F-FET.ResultsThe diagnostic accuracy of changes of the
                      TBRmean of 18F-FET PET uptake between early and late
                      examinations for the identification of HGG was 81 $\%$
                      (sensitivity 83 $\%;$ specificity 75 $\%;$ cutoff - 8 $\%;$
                      p < 0.001), and 83 $\%$ for curve pattern analysis
                      (sensitivity 88 $\%;$ specificity 75 $\%;$
                      p < 0.001).ConclusionDual-time-point imaging of 18F-FET
                      uptake in gliomas achieves diagnostic accuracy for tumour
                      grading that is similar to the more time-consuming dynamic
                      data acquisition protocol.Key Points• Dual-time-point
                      imaging is equivalent to dynamic FET PET for grading of
                      gliomas.• Dual-time-point imaging is less time consuming
                      than dynamic FET PET.• Costs can be reduced due to higher
                      patient throughput.• Reduced imaging time increases
                      patient comfort and sedation might be avoided.• Quicker
                      image interpretation is possible, as no curve evaluation is
                      necessary.},
      cin          = {INM-3 / INM-4 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000360849200025},
      doi          = {10.1007/s00330-015-3691-6},
      url          = {https://juser.fz-juelich.de/record/188717},
}