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@ARTICLE{Zhu:188777,
      author       = {Zhu, Linyan and Santiago-Schübel, Beatrix and Xiao,
                      Hongxia and Thiele, Björn and Zhu, Zhiliang and Qiu,
                      Yanling and Hollert, Henner and Küppers, Stephan},
      title        = {{A}n efficient laboratory workflow for environmental risk
                      assessment of organic chemicals},
      journal      = {Chemosphere},
      volume       = {131},
      issn         = {0045-6535},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2015-02096},
      pages        = {34 - 40},
      year         = {2015},
      abstract     = {In this study, we demonstrate a fast and efficient workflow
                      to investigate the transformation mechanism of organic
                      chemicals and evaluate the toxicity of their transformation
                      products (TPs) in laboratory scale. The transformation
                      process of organic chemicals was first simulated by
                      electrochemistry coupled online to mass spectrometry
                      (EC–MS). The simulated reactions were scaled up in a batch
                      EC reactor to receive larger amounts of a reaction mixture.
                      The mixture sample was purified and concentrated by solid
                      phase extraction (SPE) for the further ecotoxicological
                      testing. The combined toxicity of the reaction mixture was
                      evaluated in fish egg test (FET) (Danio rerio) compared to
                      the parent compound. The workflow was verified with
                      carbamazepine (CBZ). By using EC–MS seven primary TPs of
                      CBZ were identified; the degradation mechanism was
                      elucidated and confirmed by comparison to literature. The
                      reaction mixture and one primary product (acridine) showed
                      higher ecotoxicity in fish egg assay with 96 h EC50 values
                      of 1.6 and 1.0 mg L−1 than CBZ with the value of 60.8 mg
                      L−1. The results highlight the importance of
                      transformation mechanism study and toxicological effect
                      evaluation for organic chemicals brought into the
                      environment since transformation of them may increase the
                      toxicity. The developed process contributes a fast and
                      efficient laboratory method for the risk assessment of
                      organic chemicals and their TPs.},
      cin          = {ZEA-3},
      ddc          = {333.7},
      cid          = {I:(DE-Juel1)ZEA-3-20090406},
      pnm          = {255 - Terrestrial Systems: From Observation to Prediction
                      (POF3-255)},
      pid          = {G:(DE-HGF)POF3-255},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000354584600004},
      doi          = {10.1016/j.chemosphere.2015.02.031},
      url          = {https://juser.fz-juelich.de/record/188777},
}