000188883 001__ 188883
000188883 005__ 20240313094920.0
000188883 037__ $$aFZJ-2015-02184
000188883 1001_ $$0P:(DE-Juel1)159494$$aMeyes, Richard$$b0$$ufzj
000188883 1112_ $$aNWG 2015$$cGoettingen$$d2015-03-18 - 2015-03-21$$wGermanz
000188883 245__ $$aSaccade Related Layer Specific Local Field Po-tential Activity in Macaque V1 during FreeViewing
000188883 260__ $$c2015
000188883 3367_ $$0PUB:(DE-HGF)1$$2PUB:(DE-HGF)$$aAbstract$$babstract$$mabstract$$s1427780397_16439
000188883 3367_ $$033$$2EndNote$$aConference Paper
000188883 3367_ $$2DataCite$$aOutput Types/Conference Abstract
000188883 3367_ $$2ORCID$$aOTHER
000188883 3367_ $$2DRIVER$$aconferenceObject
000188883 3367_ $$2BibTeX$$aINPROCEEDINGS
000188883 520__ $$aPrimates perform frequent saccadic eye movements (SEMs) to sample visual information from theirenvironment. These SEMs are accompanied in the primary visual cortex (V1) by local fieldpotential (LFP) modulations that precede the arrival of the visual input [Ito et al. (2011) CerebCortex 21:2482-97].In the present study we aim to elucidate how the SEM related LFP modulations depend on theproperties of visual input during saccades. For this purpose, we presented stationary, full-fieldgrating stimuli to an awake macaque monkey, who freely explored the stimuli with voluntarysaccadic eye movements. Eye movements were recorded with a scleral eye coil and the LFP fromV1 with a 24-channel linear electrode array. We identified SEM related LFP modulations byaveraging the LFP signal aligned to the onsets of saccades and subsequent fixations, andreconstructed the corresponding current source density (CSD) signal (Figure a and b) from the LFPvia the inverse CSD method [Pettersen et al. (2006) J Neurosci Meth 154:116–33]. For acomparison we also computed the average LFP and CSD signal aligned to the onset of the stimulusimages preceded by fixation on a central fixation spot (Figure c).The monkey preferred to perform saccades in the direction parallel to the stripes of the stimulusimage. Those parallel saccades (PSs) had a larger median amplitude, velocity and duration thanorthogonal saccades (OSs) and intermediate saccades. We found that the SEM related LFPmodulation was stronger for OSs than for PSs. The CSD signal showed a current sink in thegranular layer, that was observed for the saccade-onset and fixation-onset triggered averages but notfor the image-onset triggered averages, confirming that this sink reflected SEM related activity(Figure a and b, red frames vs. c, red frame). The OSs evoked stronger current sinks than the PSs.We observed a positive correlation between the amplitude of saccades and the magnitude of theevoked current sink. The increase of the CSD signal for larger saccades saturated more quickly forOSs than for PSs (Figure d vs. e). This SEM related current sink probably reflects an inhibitoryprocess because it was accompanied by a concurrent decrease in high-gamma band (~160 Hz)power, which has been shown to be strongly positively correlated to the firing rates of local neurons[Ray et al. (2008) J Neurosci 28:11526-36].In summary, saccades causing larger changes in the retinal image, such as those with largeramplitude and/or in directions more orthogonal to the stripes of the stimulus images, evokedstronger CSD modulations. This seems to suggest mere excitation of V1 by the retinal changescaused by saccades, but a comparison with the concurrent high-gamma power modulation rathersuggests that the CSD modulation reflects an inhibitory process. A possible implication of theseobservations would be that the CSD signal might reflect an active suppression mechanism thatmatches the amount of inhibition to the strength of the visual input during saccades.
000188883 536__ $$0G:(DE-HGF)POF3-571$$a571 - Connectivity and Activity (POF3-571)$$cPOF3-571$$fPOF III$$x0
000188883 536__ $$0G:(DE-Juel1)HGF-SMHB-2013-2017$$aSMHB - Supercomputing and Modelling for the Human Brain (HGF-SMHB-2013-2017)$$cHGF-SMHB-2013-2017$$fSMHB$$x1
000188883 536__ $$0G:(DE-Juel1)BMBF-01GQ1116$$aBMBF-01GQ1114 - Einfluss von top-down Signalen auf den autonomen Sehvorgang - Multiskalen Analyse von massiv-parallelen Multi-Area-Daten des visuellen Pfades (BMBF-01GQ1116)$$cBMBF-01GQ1116$$fDeutschland - Japan Zusammenarbeit in Computational Neuroscience$$x2
000188883 536__ $$0G:(DE-Juel1)BMBF-01GQ1114$$aAVis - Einfluss von top-down Signalen auf den autonomen Sehvorgang - Multi-skalen Analyse von massiv-parallelen Multi-Area-Daten des visuellen Pfades (BMBF-01GQ1114)$$cBMBF-01GQ1114$$fBMBF-01GQ1114$$x3
000188883 536__ $$0G:(EU-Grant)269921$$aBRAINSCALES - Brain-inspired multiscale computation in neuromorphic hybrid systems (269921)$$c269921$$fFP7-ICT-2009-6$$x4
000188883 7001_ $$0P:(DE-Juel1)144576$$aIto, Junji$$b1$$eCorresponding Author$$ufzj
000188883 7001_ $$0P:(DE-HGF)0$$aYamane, Yukako$$b2$$eCollaboration Author
000188883 7001_ $$0P:(DE-HGF)0$$aTamura, Hiroshi$$b3$$eCollaboration Author
000188883 7001_ $$0P:(DE-HGF)0$$aFujita, Ichiro$$b4$$eCollaboration Author
000188883 7001_ $$0P:(DE-Juel1)144168$$aGrün, Sonja$$b5$$eCorresponding Author$$ufzj
000188883 773__ $$y2015
000188883 909CO $$ooai:juser.fz-juelich.de:188883$$popenaire$$pec_fundedresources$$pVDB
000188883 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)159494$$aForschungszentrum Jülich GmbH$$b0$$kFZJ
000188883 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)144576$$aForschungszentrum Jülich GmbH$$b1$$kFZJ
000188883 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)144168$$aForschungszentrum Jülich GmbH$$b5$$kFZJ
000188883 9130_ $$0G:(DE-HGF)POF2-331$$1G:(DE-HGF)POF2-330$$2G:(DE-HGF)POF2-300$$aDE-HGF$$bGesundheit$$lFunktion und Dysfunktion des Nervensystems$$vSignalling Pathways and Mechanisms in the Nervous System$$x0
000188883 9131_ $$0G:(DE-HGF)POF3-571$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vConnectivity and Activity$$x0
000188883 9141_ $$y2015
000188883 9201_ $$0I:(DE-Juel1)INM-6-20090406$$kINM-6$$lComputational and Systems Neuroscience$$x0
000188883 9201_ $$0I:(DE-Juel1)IAS-6-20130828$$kIAS-6$$lTheoretical Neuroscience$$x1
000188883 980__ $$aabstract
000188883 980__ $$aVDB
000188883 980__ $$aI:(DE-Juel1)INM-6-20090406
000188883 980__ $$aI:(DE-Juel1)IAS-6-20130828
000188883 980__ $$aUNRESTRICTED
000188883 981__ $$aI:(DE-Juel1)IAS-6-20130828
000188883 981__ $$aI:(DE-Juel1)IAS-6-20130828