000189310 001__ 189310
000189310 005__ 20210129215337.0
000189310 0247_ $$2doi$$a10.1093/brain/awu381
000189310 0247_ $$2WOS$$aWOS:000351510700023
000189310 0247_ $$2altmetric$$aaltmetric:3043641
000189310 0247_ $$2pmid$$apmid:25567321
000189310 037__ $$aFZJ-2015-02488
000189310 041__ $$aEnglish
000189310 082__ $$a610
000189310 1001_ $$0P:(DE-HGF)0$$aMichely, J.$$b0$$eCorresponding Author
000189310 245__ $$aDopaminergic modulation of motor network dynamics in Parkinson’s disease
000189310 260__ $$aOxford$$bOxford Univ. Press$$c2015
000189310 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1429075500_26842
000189310 3367_ $$2DataCite$$aOutput Types/Journal article
000189310 3367_ $$00$$2EndNote$$aJournal Article
000189310 3367_ $$2BibTeX$$aARTICLE
000189310 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000189310 3367_ $$2DRIVER$$aarticle
000189310 520__ $$aAlthough characteristic motor symptoms of Parkinson's disease such as bradykinesia typically improve under dopaminergic medication, deficits in higher motor control are less responsive. We here investigated the dopaminergic modulation of network dynamics underlying basic motor performance, i.e. finger tapping, and higher motor control, i.e. internally and externally cued movement preparation and selection. Twelve patients, assessed ON and OFF medication, and 12 age-matched healthy subjects underwent functional magnetic resonance imaging. Dynamic causal modelling was used to assess effective connectivity in a motor network comprising cortical and subcortical regions. In particular, we investigated whether impairments in basic and higher motor control, and the effects induced by dopaminergic treatment are due to connectivity changes in (i) the mesial premotor loop comprising the supplementary motor area; (ii) the lateral premotor loop comprising lateral premotor cortex; and (iii) cortico-subcortical interactions. At the behavioural level, we observed a marked slowing of movement preparation and selection when patients were internally as opposed to externally cued. Preserved performance during external cueing was associated with enhanced connectivity between prefrontal cortex and lateral premotor cortex OFF medication, compatible with a context-dependent compensatory role of the lateral premotor loop in the hypodopaminergic state. Dopaminergic medication significantly improved finger tapping speed in patients, which correlated with a drug-induced coupling increase of prefrontal cortex with the supplementary motor area, i.e. the mesial premotor loop. In addition, only in the finger tapping condition, patients ON medication showed enhanced excitatory influences exerted by cortical premotor regions and the thalamus upon the putamen. In conclusion, the amelioration of bradykinesia by dopaminergic medication seems to be driven by enhanced connectivity within the mesial premotor loop and cortico-striatal interactions. In contrast, medication did not improve internal motor control deficits concurrent to missing effects at the connectivity level. This differential effect of dopaminergic medication on the network dynamics underlying motor control provides new insights into the clinical finding that in Parkinson's disease dopaminergic drugs especially impact on bradykinesia but less on executive functions.
000189310 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x0
000189310 7001_ $$0P:(DE-HGF)0$$aVol, L. J.$$b1
000189310 7001_ $$0P:(DE-Juel1)131613$$aBarbe, Michael$$b2$$ufzj
000189310 7001_ $$0P:(DE-Juel1)131684$$aHoffstaedter, Felix$$b3$$ufzj
000189310 7001_ $$0P:(DE-Juel1)162395$$aViswanathan, Shivakumar$$b4$$ufzj
000189310 7001_ $$0P:(DE-HGF)0$$aTimmermann, L.$$b5
000189310 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon$$b6$$ufzj
000189310 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon Rudolf$$b7$$ufzj
000189310 7001_ $$0P:(DE-Juel1)161406$$aGrefkes, Christian$$b8$$ufzj
000189310 773__ $$0PERI:(DE-600)1474117-9$$a10.1093/brain/awu381$$nPt3$$p664-678$$tBrain$$v138$$x0006-8950$$y2015
000189310 8564_ $$uhttps://juser.fz-juelich.de/record/189310/files/664.full.pdf$$yRestricted
000189310 8564_ $$uhttps://juser.fz-juelich.de/record/189310/files/664.full.pdf?subformat=pdfa$$xpdfa$$yRestricted
000189310 909CO $$ooai:juser.fz-juelich.de:189310$$pVDB
000189310 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131613$$aForschungszentrum Jülich GmbH$$b2$$kFZJ
000189310 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131684$$aForschungszentrum Jülich GmbH$$b3$$kFZJ
000189310 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)162395$$aForschungszentrum Jülich GmbH$$b4$$kFZJ
000189310 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131678$$aForschungszentrum Jülich GmbH$$b6$$kFZJ
000189310 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131720$$aForschungszentrum Jülich GmbH$$b7$$kFZJ
000189310 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)161406$$aForschungszentrum Jülich GmbH$$b8$$kFZJ
000189310 9130_ $$0G:(DE-HGF)POF2-333$$1G:(DE-HGF)POF2-330$$2G:(DE-HGF)POF2-300$$aDE-HGF$$bGesundheit$$lFunktion und Dysfunktion des Nervensystems$$vPathophysiological Mechanisms of Neurological and Psychiatric Diseases$$x0
000189310 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0
000189310 9141_ $$y2015
000189310 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR
000189310 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000189310 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000189310 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000189310 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000189310 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000189310 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000189310 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000189310 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000189310 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000189310 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000189310 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10
000189310 920__ $$lyes
000189310 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
000189310 9201_ $$0I:(DE-Juel1)INM-1-20090406$$kINM-1$$lStrukturelle und funktionelle Organisation des Gehirns$$x1
000189310 980__ $$ajournal
000189310 980__ $$aVDB
000189310 980__ $$aI:(DE-Juel1)INM-3-20090406
000189310 980__ $$aI:(DE-Juel1)INM-1-20090406
000189310 980__ $$aUNRESTRICTED
000189310 981__ $$aI:(DE-Juel1)INM-1-20090406