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@ARTICLE{Michely:189310,
      author       = {Michely, J. and Vol, L. J. and Barbe, Michael and
                      Hoffstaedter, Felix and Viswanathan, Shivakumar and
                      Timmermann, L. and Eickhoff, Simon and Fink, Gereon Rudolf
                      and Grefkes, Christian},
      title        = {{D}opaminergic modulation of motor network dynamics in
                      {P}arkinson’s disease},
      journal      = {Brain},
      volume       = {138},
      number       = {Pt3},
      issn         = {0006-8950},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2015-02488},
      pages        = {664-678},
      year         = {2015},
      abstract     = {Although characteristic motor symptoms of Parkinson's
                      disease such as bradykinesia typically improve under
                      dopaminergic medication, deficits in higher motor control
                      are less responsive. We here investigated the dopaminergic
                      modulation of network dynamics underlying basic motor
                      performance, i.e. finger tapping, and higher motor control,
                      i.e. internally and externally cued movement preparation and
                      selection. Twelve patients, assessed ON and OFF medication,
                      and 12 age-matched healthy subjects underwent functional
                      magnetic resonance imaging. Dynamic causal modelling was
                      used to assess effective connectivity in a motor network
                      comprising cortical and subcortical regions. In particular,
                      we investigated whether impairments in basic and higher
                      motor control, and the effects induced by dopaminergic
                      treatment are due to connectivity changes in (i) the mesial
                      premotor loop comprising the supplementary motor area; (ii)
                      the lateral premotor loop comprising lateral premotor
                      cortex; and (iii) cortico-subcortical interactions. At the
                      behavioural level, we observed a marked slowing of movement
                      preparation and selection when patients were internally as
                      opposed to externally cued. Preserved performance during
                      external cueing was associated with enhanced connectivity
                      between prefrontal cortex and lateral premotor cortex OFF
                      medication, compatible with a context-dependent compensatory
                      role of the lateral premotor loop in the hypodopaminergic
                      state. Dopaminergic medication significantly improved finger
                      tapping speed in patients, which correlated with a
                      drug-induced coupling increase of prefrontal cortex with the
                      supplementary motor area, i.e. the mesial premotor loop. In
                      addition, only in the finger tapping condition, patients ON
                      medication showed enhanced excitatory influences exerted by
                      cortical premotor regions and the thalamus upon the putamen.
                      In conclusion, the amelioration of bradykinesia by
                      dopaminergic medication seems to be driven by enhanced
                      connectivity within the mesial premotor loop and
                      cortico-striatal interactions. In contrast, medication did
                      not improve internal motor control deficits concurrent to
                      missing effects at the connectivity level. This differential
                      effect of dopaminergic medication on the network dynamics
                      underlying motor control provides new insights into the
                      clinical finding that in Parkinson's disease dopaminergic
                      drugs especially impact on bradykinesia but less on
                      executive functions.},
      cin          = {INM-3 / INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-1-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000351510700023},
      pubmed       = {pmid:25567321},
      doi          = {10.1093/brain/awu381},
      url          = {https://juser.fz-juelich.de/record/189310},
}