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@ARTICLE{WeissBlankenhorn:189312,
      author       = {Weiss-Blankenhorn, Peter and Herzog, J. and Pötter-Nerger,
                      M. and Falk, D. and Herzog, Hans and Deuschl, G. and
                      Volkmann, J. and Fink, Gereon Rudolf},
      title        = {{S}ubthalamic nucleus stimulation improves {P}arkinsonian
                      gait via brainstem locomotor centers},
      journal      = {Movement disorders},
      volume       = {30},
      number       = {8},
      issn         = {0885-3185},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {FZJ-2015-02490},
      pages        = {1121 – 1125},
      year         = {2015},
      abstract     = {Subthalamic deep brain stimulation (STN-DBS) can ameliorate
                      gait disturbances in Parkinson's disease (PD). Using motor
                      imagery and positron emission tomography (PET), we
                      investigated how STN-DBS interacts with supraspinal
                      locomotor centers in PD.Ten PD patients with bilateral
                      STN-DBS actually walked or stood still under STN-DBS ON or
                      OFF conditions. Directly thereafter, subjects imagined
                      walking or standing while changes in regional cerebral blood
                      flow were measured by PET.Independent of STN-DBS, imagined
                      walking distance correlated with imagery duration. Compared
                      with STN-DBS OFF, STN-DBS ON improved actual gait and
                      increased imagined walking distance. Imagery of gait (vs.
                      stance) induced activity in the supplementary motor area and
                      the right superior parietal lobule for both STN-DBS
                      conditions. The improvement of imagined gait during STN-DBS
                      ON led to activity changes in the pedunculopontine
                      nucleus/mesencephalic locomotor region (PPN/MLR).Data
                      suggest that STN-DBS improves Parkinsonian gait by
                      modulating PPN/MLR activity. © 2015 International Parkinson
                      and Movement Disorder Society},
      cin          = {INM-3 / INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000357945600018},
      pubmed       = {pmid:25914247},
      doi          = {10.1002/mds.26229},
      url          = {https://juser.fz-juelich.de/record/189312},
}