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@ARTICLE{ODushlaine:189359,
author = {O'Dushlaine, Colm and Rossin, Lizzy and Lee, Phil H and
Duncan, Laramie and Parikshak, Neelroop N and Newhouse,
Stephen and Ripke, Stephan and Neale, Benjamin M and
Purcell, Shaun M and Posthuma, Danielle and Nurnberger, John
I and Lee, S Hong and Faraone, Stephen V and Perlis, Roy H
and Mowry, Bryan J and Thapar, Anita and Goddard, Michael E
and Witte, John S and Absher, Devin and Agartz, Ingrid and
Akil, Huda and Amin, Farooq and Andreassen, Ole A and
Anjorin, Adebayo and Anney, Richard and Anttila, Verneri and
Arking, Dan E and Asherson, Philip and Azevedo, Maria H and
Backlund, Lena and Badner, Judith A and Bailey, Anthony J
and Banaschewski, Tobias and Barchas, Jack D and Barnes,
Michael R and Barrett, Thomas B and Bass, Nicholas and
Battaglia, Agatino and Bauer, Michael and Bayés, Mònica
and Bellivier, Frank and Bergen, Sarah E and Berrettini,
Wade and Betancur, Catalina and Bettecken, Thomas and
Biederman, Joseph and Binder, Elisabeth B and Black, Donald
W and Blackwood, Douglas H R and Bloss, Cinnamon S and
Boehnke, Michael and Boomsma, Dorret I and Breuer, René and
Bruggeman, Richard and Cormican, Paul and Buccola, Nancy G
and Buitelaar, Jan K and Bunney, William E and Buxbaum,
Joseph D and Byerley, William F and Byrne, Enda M and
Caesar, Sian and Cahn, Wiepke and Cantor, Rita M and Casas,
Miguel and Chakravarti, Aravinda and Chambert, Kimberly and
Choudhury, Khalid and Cichon, Sven and Mattheisen, Manuel
and Cloninger, C Robert and Collier, David A and Cook, Edwin
H and Coon, Hilary and Cormand, Bru and Corvin, Aiden and
Coryell, William H and Craig, David W and Craig, Ian W and
Crosbie, Jennifer and Cuccaro, Michael L and Curtis, David
and Czamara, Darina and Datta, Susmita and Dawson, Geraldine
and Day, Richard and De Geus, Eco J and Degenhardt,
Franziska and Djurovic, Srdjan and Donohoe, Gary J and
Doyle, Alysa E and Duan, Jubao and Dudbridge, Frank and
Duketis, Eftichia and Ebstein, Richard P and Edenberg,
Howard J and Elia, Josephine and Ennis, Sean and Etain,
Bruno and Fanous, Ayman and Farmer, Anne E and Ferrier, I
Nicol and Flickinger, Matthew and Fombonne, Eric and Foroud,
Tatiana and Frank, Josef and Franke, Barbara and Fraser,
Christine and Freedman, Robert and Freimer, Nelson B and
Freitag, Christine M and Friedl, Marion and Frisén, Louise
and Gallagher, Louise and Gejman, Pablo V and Georgieva,
Lyudmila and Gershon, Elliot S and Giegling, Ina and Gill,
Michael and Gordon, Scott D and Gordon-Smith, Katherine and
Green, Elaine K and Greenwood, Tiffany A and Grice, Dorothy
E and Gross, Magdalena and Grozeva, Detelina and Guan,
Weihua and Gurling, Hugh and De Haan, Lieuwe and Haines,
Jonathan L and Hakonarson, Hakon and Hallmayer, Joachim and
Hamilton, Steven P and Hamshere, Marian L and Hansen, Thomas
F and Hartmann, Annette M and Hautzinger, Martin and Heath,
Andrew C and Henders, Anjali K and Herms, Stefan and Hickie,
Ian B and Hipolito, Maria and Hoefels, Susanne and Holsboer,
Florian and Hoogendijk, Witte J and Hottenga, Jouke-Jan and
Hultman, Christina M and Hus, Vanessa and Ingason, Andrés
and Ising, Marcus and Jamain, Stéphane and Jones, Edward G
and Jones, Ian and Jones, Lisa and Tzeng, Jung-Ying and
Kähler, Anna K and Kahn, René S and Kandaswamy, Radhika
and Keller, Matthew C and Kennedy, James L and Kenny, Elaine
and Kent, Lindsey and Kim, Yunjung and Kirov, George K and
Klauck, Sabine M and Klei, Lambertus and Knowles, James A
and Kohli, Martin A and Koller, Daniel L and Konte, Bettina
and Korszun, Ania and Krabbendam, Lydia and Krasucki, Robert
and Kuntsi, Jonna and Kwan, Phoenix and Landén, Mikael and
Längström, Niklas and Lathrop, Mark and Lawrence, Jacob
and Lawson, William B and Leboyer, Marion and Ledbetter,
David H and Lencz, Todd and Lesch, Klaus-Peter and Levinson,
Douglas F and Lewis, Cathryn M and Li, Jun and Lichtenstein,
Paul and Lieberman, Jeffrey A and Lin, Dan-Yu and Linszen,
Don H and Liu, Chunyu and Lohoff, Falk W and Loo, Sandra K
and Lord, Catherine and Lowe, Jennifer K and Lucae, Susanne
and MacIntyre, Donald J and Madden, Pamela A F and
Maestrini, Elena and Magnusson, Patrik K E and Mahon, Pamela
B and Maier, Wolfgang and Malhotra, Anil K and Mane,
Shrikant M and Martin, Christa L and Martin, Nicholas G and
Matthews, Keith and Mattingsdal, Morten and McCarroll,
Steven A and McGhee, Kevin A and McGough, James J and
McGrath, Patrick J and McGuffin, Peter and McInnis, Melvin G
and McIntosh, Andrew and McKinney, Rebecca and McLean, Alan
W and McMahon, Francis J and McMahon, William M and
McQuillin, Andrew and Medeiros, Helena and Medland, Sarah E
and Meier, Sandra and Melle, Ingrid and Meng, Fan and Meyer,
Jobst and Middeldorp, Christel M and Middleton, Lefkos and
Milanova, Vihra and Miranda, Ana and Monaco, Anthony P and
Montgomery, Grant W and Moran, Jennifer L and
Moreno-De-Luca, Daniel and Morken, Gunnar and Morris, Derek
W and Morrow, Eric M and Moskvina, Valentina and Muglia,
Pierandrea and Mühleisen, Thomas W and Muir, Walter J and
Müller-Myhsok, Bertram and Murtha, Michael and Myers,
Richard M and Myin-Germeys, Inez and Neale, Michael C and
Nelson, Stan F and Nievergelt, Caroline M and Nikolov, Ivan
and Nimgaonkar, Vishwajit and Nolen, Willem A and Nöthen,
Markus M and Nwulia, Evaristus A and Nyholt, Dale R and
Oades, Robert D and Olincy, Ann and Oliveira, Guiomar and
Olsen, Line and Ophoff, Roel A and Osby, Urban and Owen,
Michael J and Palotie, Aarno and Parr, Jeremy R and
Paterson, Andrew D and Pato, Carlos N and Pato, Michele T
and Penninx, Brenda W and Pergadia, Michele L and
Pericak-Vance, Margaret A and Pickard, Benjamin S and Pimm,
Jonathan and Piven, Joseph and Potash, James B and Poustka,
Fritz and Propping, Peter and Puri, Vinay and Quested, Digby
J and Quinn, Emma M and Ramos-Quiroga, Josep Antoni and
Rasmussen, Henrik B and Raychaudhuri, Soumya and Rehnström,
Karola and Reif, Andreas and Ribasés, Marta and Rice, John
P and Rietschel, Marcella and Roeder, Kathryn and Roeyers,
Herbert and Rothenberger, Aribert and Rouleau, Guy and
Ruderfer, Douglas and Rujescu, Dan and Sanders, Alan R and
Sanders, Stephan J and Santangelo, Susan L and Sergeant,
Joseph A and Schachar, Russell and Schalling, Martin and
Schatzberg, Alan F and Scheftner, William A and
Schellenberg, Gerard D and Scherer, Stephen W and Schork,
Nicholas J and Schulze, Thomas G and Schumacher, Johannes
and Schwarz, Markus and Scolnick, Edward and Scott, Laura J
and Shi, Jianxin and Shilling, Paul D and Shyn, Stanley I
and Silverman, Jeremy M and Slager, Susan L and Smalley,
Susan L and Smit, Johannes H and Smith, Erin N and
Sonuga-Barke, Edmund J S and Clair, David St. and State,
Matthew and Steffens, Michael and Steinhausen,
Hans-Christoph and Strauss, John S and Strohmaier, Jana and
Stroup, T Scott and Sutcliffe, James S and Szatmari, Peter
and Szelinger, Szabocls and Thirumalai, Srinivasa and
Thompson, Robert C and Todorov, Alexandre A and Tozzi,
Federica and Treutlein, Jens and Uhr, Manfred and van den
Oord, Edwin J C G and Van Grootheest, Gerard and Van Os, Jim
and Vicente, Astrid M and Vieland, Veronica J and Vincent,
John B and Visscher, Peter M and Walsh, Christopher A and
Wassink, Thomas H and Watson, Stanley J and Weissman, Myrna
M and Werge, Thomas and Wienker, Thomas F and Wijsman, Ellen
M and Willemsen, Gonneke and Williams, Nigel and Willsey, A
Jeremy and Witt, Stephanie H and Xu, Wei and Young, Allan H
and Yu, Timothy W and Zammit, Stanley and Zandi, Peter P and
Zhang, Peng and Zitman, Frans G and Zöllner, Sebastian and
Devlin, Bernie and Kelsoe, John R and Sklar, Pamela and
Daly, Mark J and O'Donovan, Michael C and Craddock, Nicholas
and Kendler, Kenneth S and A Weiss, Lauren and Wray, Naomi R
and Zhao, Zhaoming and Geschwind, Daniel H and Sullivan,
Patrick F and Smoller, Jordan W and Holmans, Peter A and
Breen, Gerome},
title = {{P}sychiatric genome-wide association study analyses
implicate neuronal, immune and histone pathways},
journal = {Nature neuroscience},
volume = {18},
number = {2},
issn = {1097-6256},
address = {New York, NY},
publisher = {Nature America},
reportid = {FZJ-2015-02537},
pages = {199 - 209},
year = {2015},
abstract = {Genome-wide association studies (GWAS) of psychiatric
disorders have identified multiple genetic associations with
such disorders, but better methods are needed to derive the
underlying biological mechanisms that these signals
indicate. We sought to identify biological pathways in GWAS
data from over 60,000 participants from the Psychiatric
Genomics Consortium. We developed an analysis framework to
rank pathways that requires only summary statistics. We
combined this score across disorders to find common pathways
across three adult psychiatric disorders: schizophrenia,
major depression and bipolar disorder. Histone methylation
processes showed the strongest association, and we also
found statistically significant evidence for associations
with multiple immune and neuronal signaling pathways and
with the postsynaptic density. Our study indicates that risk
variants for psychiatric disorders aggregate in particular
biological pathways and that these pathways are frequently
shared between disorders. Our results confirm known
mechanisms and suggest several novel insights into the
etiology of psychiatric disorders.},
cin = {INM-1},
ddc = {590},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {571 - Connectivity and Activity (POF3-571)},
pid = {G:(DE-HGF)POF3-571},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000348631800010},
pubmed = {pmid:25599223},
doi = {10.1038/nn.3922},
url = {https://juser.fz-juelich.de/record/189359},
}
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