001     189359
005     20210129215344.0
024 7 _ |a 10.1038/nn.3922
|2 doi
024 7 _ |a 1097-6256
|2 ISSN
024 7 _ |a 1471-003X
|2 ISSN
024 7 _ |a 1471-0048
|2 ISSN
024 7 _ |a 1546-1726
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037 _ _ |a FZJ-2015-02537
082 _ _ |a 590
100 1 _ |a O'Dushlaine, Colm
|b 0
245 _ _ |a Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
260 _ _ |a New York, NY
|c 2015
|b Nature America
336 7 _ |a Journal Article
|b journal
|m journal
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|s 1428931228_30909
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336 7 _ |a ARTICLE
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336 7 _ |a article
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520 _ _ |a Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought to identify biological pathways in GWAS data from over 60,000 participants from the Psychiatric Genomics Consortium. We developed an analysis framework to rank pathways that requires only summary statistics. We combined this score across disorders to find common pathways across three adult psychiatric disorders: schizophrenia, major depression and bipolar disorder. Histone methylation processes showed the strongest association, and we also found statistically significant evidence for associations with multiple immune and neuronal signaling pathways and with the postsynaptic density. Our study indicates that risk variants for psychiatric disorders aggregate in particular biological pathways and that these pathways are frequently shared between disorders. Our results confirm known mechanisms and suggest several novel insights into the etiology of psychiatric disorders.
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920 1 _ |0 I:(DE-Juel1)INM-1-20090406
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|l Strukturelle und funktionelle Organisation des Gehirns
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-Juel1)INM-1-20090406
980 _ _ |a UNRESTRICTED


LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21