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@ARTICLE{Weiss:189739,
      author       = {Weiss, Carolin and Tursunova, Irada and Neuschmelting,
                      Volker and Lockau, Hannah and Nettekoven, Charlotte and
                      Oros-Peusquens, Ana-Maria and Stoffels, Gabriele and Rehme,
                      Anne K. and Faymonville, Andrea Maria and Shah, N. J. and
                      Langen, Karl Josef and Goldbrunner, Roland and Grefkes,
                      Christian},
      title        = {{I}mproved n{TMS}- and {DTI}-derived {CST} tractography
                      through anatomical {ROI} seeding on anterior pontine level
                      compared to internal capsule},
      journal      = {NeuroImage: Clinical},
      volume       = {7},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2015-02771},
      pages        = {424 - 437},
      year         = {2015},
      abstract     = {Imaging of the course of the corticospinal tract (CST) by
                      diffusion tensor imaging (DTI) is useful for
                      function-preserving tumour surgery. The integration of
                      functional localizer data into tracking algorithms offers to
                      establish a direct structure–function relationship in DTI
                      data. However, alterations of MRI signals in and adjacent to
                      brain tumours often lead to spurious tracking results. We
                      here compared the impact of subcortical seed regions placed
                      at different positions and the influences of the somatotopic
                      location of the cortical seed and clinical co-factors on
                      fibre tracking plausibility in brain tumour patients.The CST
                      of 32 patients with intracranial tumours was investigated by
                      means of deterministic DTI and neuronavigated transcranial
                      magnetic stimulation (nTMS). The cortical seeds were defined
                      by the nTMS hot spots of the primary motor area (M1) of the
                      hand, the foot and the tongue representation. The CST
                      originating from the contralesional M1 hand area was mapped
                      as intra-individual reference. As subcortical region of
                      interests (ROI), we used the posterior limb of the internal
                      capsule (PLIC) and/or the anterior inferior pontine region
                      (aiP). The plausibility of the fibre trajectories was
                      assessed by a-priori defined anatomical criteria. The
                      following potential co-factors were analysed: Karnofsky
                      Performance Scale (KPS), resting motor threshold (RMT),
                      T1-CE tumour volume, T2 oedema volume, presence of oedema
                      within the PLIC, the fractional anisotropy threshold (FAT)
                      to elicit a minimum amount of fibres and the minimal fibre
                      length.The results showed a higher proportion of plausible
                      fibre tracts for the aiP-ROI compared to the PLIC-ROI. Low
                      FAT values and the presence of peritumoural oedema within
                      the PLIC led to less plausible fibre tracking results. Most
                      plausible results were obtained when the FAT ranged above a
                      cut-off of 0.105. In addition, there was a strong effect of
                      somatotopic location of the seed ROI; best plausibility was
                      obtained for the contralateral hand CST $(100\%),$ followed
                      by the ipsilesional hand CST $(>95\%),$ the ipsilesional
                      foot $(>85\%)$ and tongue $(>75\%)$ CST. In summary, we
                      found that the aiP-ROI yielded better tracking results
                      compared to the IC-ROI when using deterministic CST
                      tractography in brain tumour patients, especially when the
                      M1 hand area was tracked. In case of FAT values lower than
                      0.10, the result of the respective CST tractography should
                      be interpreted with caution with respect to spurious
                      tracking results. Moreover, the presence of oedema within
                      the internal capsule should be considered a negative
                      predictor for plausible CST tracking.},
      cin          = {INM-4 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-3-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000373172600047},
      pubmed       = {pmid:25685709},
      doi          = {10.1016/j.nicl.2015.01.006},
      url          = {https://juser.fz-juelich.de/record/189739},
}