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000189740 1001_ $$0P:(DE-Juel1)162203$$aReetz, Kathrin$$b0$$eCorresponding Author
000189740 245__ $$aIncreased Cerebral Water Content in Hemodialysis Patients
000189740 260__ $$aLawrence, Kan.$$bPLoS$$c2015
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000189740 520__ $$aLittle information is available on the impact of hemodialysis on cerebral water homeostasis and its distribution in chronic kidney disease. We used a neuropsychological test battery, structural magnetic resonance imaging (MRI) and a novel technique for quantitative measurement of localized water content using 3T MRI to investigate ten hemodialysis patients (HD) on a dialysis-free day and after hemodialysis (2.4±2.2 hours), and a matched healthy control group with the same time interval. Neuropsychological testing revealed mainly attentional and executive cognitive dysfunction in HD. Voxel-based-morphometry showed only marginal alterations in the right inferior medial temporal lobe white matter in HD compared to controls. Marked increases in global brain water content were found in the white matter, specifically in parietal areas, in HD patients compared to controls. Although the global water content in the gray matter did not differ between the two groups, regional increases of brain water content in particular in parieto-temporal gray matter areas were observed in HD patients. No relevant brain hydration changes were revealed before and after hemodialysis. Whereas longer duration of dialysis vintage was associated with increased water content in parieto-temporal-occipital regions, lower intradialytic weight changes were negatively correlated with brain water content in these areas in HD patients. Worse cognitive performance on an attention task correlated with increased hydration in frontal white matter. In conclusion, long-term HD is associated with altered brain tissue water homeostasis mainly in parietal white matter regions, whereas the attentional domain in the cognitive dysfunction profile in HD could be linked to increased frontal white matter water content.
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000189740 7001_ $$0P:(DE-Juel1)140186$$aAbbas, Zaheer$$b1$$ufzj
000189740 7001_ $$0P:(DE-HGF)0$$aCosta, Ana Sofia$$b2
000189740 7001_ $$0P:(DE-Juel1)131765$$aGras, Vincent$$b3
000189740 7001_ $$0P:(DE-HGF)0$$aTiffin-Richards, Frances$$b4
000189740 7001_ $$0P:(DE-HGF)0$$aMirzazade, Shahram$$b5
000189740 7001_ $$0P:(DE-HGF)0$$aHolschbach, Bernhard$$b6
000189740 7001_ $$0P:(DE-HGF)0$$aFrank, Rolf Dario$$b7
000189740 7001_ $$0P:(DE-HGF)0$$aVassiliadou, Athina$$b8
000189740 7001_ $$0P:(DE-HGF)0$$aKrüger, Thilo$$b9
000189740 7001_ $$0P:(DE-HGF)0$$aEitner, Frank$$b10
000189740 7001_ $$0P:(DE-HGF)0$$aGross, Theresa$$b11
000189740 7001_ $$0P:(DE-HGF)0$$aSchulz, Jörg Bernhard$$b12
000189740 7001_ $$0P:(DE-HGF)0$$aFloege, Jürgen$$b13
000189740 7001_ $$0P:(DE-Juel1)131794$$aShah, N. J.$$b14$$ufzj
000189740 773__ $$0PERI:(DE-600)2267670-3$$a10.1371/journal.pone.0122188$$gVol. 10, no. 3, p. e0122188 -$$n3$$pe0122188 -$$tPLoS one$$v10$$x1932-6203$$y2015
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