% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Reetz:189740,
      author       = {Reetz, Kathrin and Abbas, Zaheer and Costa, Ana Sofia and
                      Gras, Vincent and Tiffin-Richards, Frances and Mirzazade,
                      Shahram and Holschbach, Bernhard and Frank, Rolf Dario and
                      Vassiliadou, Athina and Krüger, Thilo and Eitner, Frank and
                      Gross, Theresa and Schulz, Jörg Bernhard and Floege,
                      Jürgen and Shah, N. J.},
      title        = {{I}ncreased {C}erebral {W}ater {C}ontent in {H}emodialysis
                      {P}atients},
      journal      = {PLoS one},
      volume       = {10},
      number       = {3},
      issn         = {1932-6203},
      address      = {Lawrence, Kan.},
      publisher    = {PLoS},
      reportid     = {FZJ-2015-02772},
      pages        = {e0122188 -},
      year         = {2015},
      abstract     = {Little information is available on the impact of
                      hemodialysis on cerebral water homeostasis and its
                      distribution in chronic kidney disease. We used a
                      neuropsychological test battery, structural magnetic
                      resonance imaging (MRI) and a novel technique for
                      quantitative measurement of localized water content using 3T
                      MRI to investigate ten hemodialysis patients (HD) on a
                      dialysis-free day and after hemodialysis (2.4±2.2 hours),
                      and a matched healthy control group with the same time
                      interval. Neuropsychological testing revealed mainly
                      attentional and executive cognitive dysfunction in HD.
                      Voxel-based-morphometry showed only marginal alterations in
                      the right inferior medial temporal lobe white matter in HD
                      compared to controls. Marked increases in global brain water
                      content were found in the white matter, specifically in
                      parietal areas, in HD patients compared to controls.
                      Although the global water content in the gray matter did not
                      differ between the two groups, regional increases of brain
                      water content in particular in parieto-temporal gray matter
                      areas were observed in HD patients. No relevant brain
                      hydration changes were revealed before and after
                      hemodialysis. Whereas longer duration of dialysis vintage
                      was associated with increased water content in
                      parieto-temporal-occipital regions, lower intradialytic
                      weight changes were negatively correlated with brain water
                      content in these areas in HD patients. Worse cognitive
                      performance on an attention task correlated with increased
                      hydration in frontal white matter. In conclusion, long-term
                      HD is associated with altered brain tissue water homeostasis
                      mainly in parietal white matter regions, whereas the
                      attentional domain in the cognitive dysfunction profile in
                      HD could be linked to increased frontal white matter water
                      content.},
      cin          = {INM-4},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-4-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000352084800060},
      pubmed       = {pmid:25826269},
      doi          = {10.1371/journal.pone.0122188},
      url          = {https://juser.fz-juelich.de/record/189740},
}