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@ARTICLE{Zimmermann:190166,
      author       = {Zimmermann, E. and Ostendorf, F. and Ploner, C. J. and
                      Lappe, M.},
      title        = {{I}mpairment of saccade adaptation in a patient with a
                      focal thalamic lesion},
      journal      = {Journal of neurophysiology},
      volume       = {113},
      number       = {7},
      issn         = {1522-1598},
      address      = {Bethesda, Md.},
      publisher    = {Soc.},
      reportid     = {FZJ-2015-03095},
      pages        = {2351 - 2359},
      year         = {2015},
      abstract     = {The frequent jumps of the eyeballs—called
                      saccades—imply the need for a constant correction of motor
                      errors. If systematic errors are detected in saccade
                      landing, the saccade amplitude adapts to compensate for the
                      error. In the laboratory, saccade adaptation can be studied
                      by displacing the saccade target. Functional selectivity of
                      adaptation for different saccade types suggests that
                      adaptation occurs at multiple sites in the oculomotor
                      system. Saccade motor learning might be the result of a
                      comparison between a prediction of the saccade landing
                      position and its actual postsaccadic location. To
                      investigate whether a thalamic feedback pathway might carry
                      such a prediction signal, we studied a patient with a lesion
                      in the posterior ventrolateral thalamic nucleus. Saccade
                      adaptation was tested for reactive saccades, which are
                      performed to suddenly appearing targets, and for scanning
                      saccades, which are performed to stationary targets. For
                      reactive saccades, we found a clear impairment in adaptation
                      retention ipsilateral to the lesioned side and a
                      larger-than-normal adaptation on the contralesional side.
                      For scanning saccades, adaptation was intact on both sides
                      and not different from the control group. Our results
                      provide the first lesion evidence that adaptation of
                      reactive and scanning saccades relies on distinct feedback
                      pathways from cerebellum to cortex. They further demonstrate
                      that saccade adaptation in humans is not restricted to the
                      cerebellum but also involves cortical areas. The
                      paradoxically strong adaptation for outward target steps can
                      be explained by stronger reliance on visual targeting errors
                      when prediction error signaling is impaired.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000355000900034},
      pubmed       = {pmid:25652924},
      doi          = {10.1152/jn.00744.2014},
      url          = {https://juser.fz-juelich.de/record/190166},
}