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000019204 084__ $$2WoS$$aClinical Neurology
000019204 084__ $$2WoS$$aPsychiatry
000019204 1001_ $$0P:(DE-Juel1)VDB73298$$aGalldiks, N.$$b0$$uFZJ
000019204 245__ $$aAnwendung der Aminosäure-PET in der Diagnostik und Therapie von zerebralen Gliomen (Use of amino acid PET in the diagnostic and treatment management of cerebral gliomas)
000019204 260__ $$aStuttgart [u.a.]$$bThieme$$c2012
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000019204 440_0 $$018781$$aFortschritte der Neurologie  Psychiatrie$$v80$$x0720-4299$$y1
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000019204 520__ $$aStructural as well as functional imaging methods are of special importance in neurooncology. Improvements of radionuclide and magnetic resonance-based imaging modalities over the past decade have enabled clinicians to non-invasively assess the dynamics of disease-specific processes at the molecular level in patients with malignant gliomas. To date, a range of complementary imaging parameters have been established in the diagnostic work-up of patients with brain tumours. Magnetic resonance imaging (MRI) provides morphological information as well as functional information such as vascular permeability, cell density, tumour perfusion, and metabolic information by using magnetic resonance spectroscopy. The use of radiolabelled amino acids for positron emission tomography (PET) allows a better delineation of tumour margins and improves targeting of biopsy and radiotherapy, and planning surgery. In addition, amino acid imaging appears useful in distinguishing tumour recurrence from non-specific post-therapeutic scar tissue, in predicting prognosis in low-grade gliomas, and in monitoring metabolic response during treatment. Taken together, MRI and PET provide complementary information about tumour biology and activity, thereby resulting in an improved understanding of the kinetics of tumour growth and therefore allow new insights into the pathophysiology of malignant brain tumours. However, multimodal imaging studies comparing the value of amino acid PET and functional methods of MRI (e. g., perfusion and diffusion weighted imaging) are needed. From these studies, surrogate MRI and PET imaging techniques need to be derived to gain complementary structural and functional information of brain tumours that can be placed into common clinical practice which will optimise the clinical management of patients with malignant gliomas.
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000019204 650_2 $$2MeSH$$aAmino Acids: diagnostic use
000019204 650_2 $$2MeSH$$aBiopsy
000019204 650_2 $$2MeSH$$aBrain: pathology
000019204 650_2 $$2MeSH$$aBrain: radionuclide imaging
000019204 650_2 $$2MeSH$$aBrain Neoplasms: pathology
000019204 650_2 $$2MeSH$$aBrain Neoplasms: radionuclide imaging
000019204 650_2 $$2MeSH$$aBrain Neoplasms: therapy
000019204 650_2 $$2MeSH$$aCombined Modality Therapy
000019204 650_2 $$2MeSH$$aGlioma: pathology
000019204 650_2 $$2MeSH$$aGlioma: radionuclide imaging
000019204 650_2 $$2MeSH$$aGlioma: therapy
000019204 650_2 $$2MeSH$$aHumans
000019204 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000019204 650_2 $$2MeSH$$aNeoplasm Recurrence, Local
000019204 650_2 $$2MeSH$$aNeurosurgical Procedures
000019204 650_2 $$2MeSH$$aPatient Care Planning
000019204 650_2 $$2MeSH$$aPositron-Emission Tomography: methods
000019204 650_2 $$2MeSH$$aPrognosis
000019204 650_2 $$2MeSH$$aRadiopharmaceuticals: diagnostic use
000019204 650_7 $$00$$2NLM Chemicals$$aAmino Acids
000019204 650_7 $$00$$2NLM Chemicals$$aRadiopharmaceuticals
000019204 650_7 $$2WoSType$$aJ
000019204 65320 $$2Author$$aC-11-methyl-L-methionine
000019204 65320 $$2Author$$aO-(2-[F-18]-fluoroethyl)-L-tyrosine
000019204 65320 $$2Author$$ametabolic imaging
000019204 7001_ $$0P:(DE-Juel1)131777$$aLangen, K.-J.$$b1$$uFZJ
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000019204 8567_ $$uhttp://dx.doi.org/10.1055/s-0031-1281851
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