000019623 001__ 19623
000019623 005__ 20240610120840.0
000019623 0247_ $$2pmid$$apmid:21988913
000019623 0247_ $$2DOI$$a10.1038/ncomms1499
000019623 0247_ $$2WOS$$aWOS:000296787300010
000019623 0247_ $$2altmetric$$aaltmetric:404571
000019623 0247_ $$2Handle$$a2128/24486
000019623 0247_ $$2ISSN$$a2041-1723
000019623 037__ $$aPreJuSER-19623
000019623 041__ $$aeng
000019623 082__ $$a500
000019623 084__ $$2WoS$$aMultidisciplinary Sciences
000019623 1001_ $$0P:(DE-HGF)0$$aAtkinson, J.$$b0
000019623 245__ $$aA mitochondrial-targeted inhibitor of cytochrorme c peroxidase mitigates radiation-induced death
000019623 260__ $$aLondon$$bNature Publishing Group$$c2011
000019623 300__ $$a497
000019623 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
000019623 3367_ $$2DataCite$$aOutput Types/Journal article
000019623 3367_ $$00$$2EndNote$$aJournal Article
000019623 3367_ $$2BibTeX$$aARTICLE
000019623 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000019623 3367_ $$2DRIVER$$aarticle
000019623 440_0 $$025143$$aNature Communications$$v2
000019623 520__ $$aThe risk of radionuclide release in terrorist acts or exposure of healthy tissue during radiotherapy demand potent radioprotectants/radiomitigators. Ionizing radiation induces cell death by initiating the selective peroxidation of cardiolipin in mitochondria by the peroxidase activity of its complex with cytochrome c leading to release of haemoprotein into the cytosol and commitment to the apoptotic program. Here we design and synthesize mitochondria-targeted triphenylphosphonium-conjugated imidazole-substituted oleic and stearic acids that blocked peroxidase activity of cytochrome c/cardiolipin complex by specifically binding to its haem-iron. We show that both compounds inhibit pro-apoptotic oxidative events, suppress cyt c release, prevent cell death, and protect mice against lethal doses of irradiation. Significant radioprotective/radiomitigative effects of imidazole-substituted oleic acid are observed after pretreatment of mice from 1 h before through 24 h after the irradiation.
000019623 536__ $$0G:(DE-Juel1)FUEK505$$2G:(DE-HGF)$$aBioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung$$cP45$$x0
000019623 588__ $$aDataset connected to Web of Science, Pubmed
000019623 650_2 $$2MeSH$$aAnimals
000019623 650_2 $$2MeSH$$aCell Death: drug effects
000019623 650_2 $$2MeSH$$aCell Death: radiation effects
000019623 650_2 $$2MeSH$$aCytochrome-c Peroxidase: antagonists & inhibitors
000019623 650_2 $$2MeSH$$aElectron Spin Resonance Spectroscopy
000019623 650_2 $$2MeSH$$aEnzyme Inhibitors: chemistry
000019623 650_2 $$2MeSH$$aEnzyme Inhibitors: pharmacology
000019623 650_2 $$2MeSH$$aFemale
000019623 650_2 $$2MeSH$$aMice
000019623 650_2 $$2MeSH$$aMice, Inbred C57BL
000019623 650_2 $$2MeSH$$aMitochondria: drug effects
000019623 650_2 $$2MeSH$$aMitochondria: enzymology
000019623 650_2 $$2MeSH$$aModels, Molecular
000019623 650_2 $$2MeSH$$aMolecular Dynamics Simulation
000019623 650_2 $$2MeSH$$aRadiation-Protective Agents: chemistry
000019623 650_2 $$2MeSH$$aRadiation-Protective Agents: pharmacology
000019623 650_7 $$00$$2NLM Chemicals$$aEnzyme Inhibitors
000019623 650_7 $$00$$2NLM Chemicals$$aRadiation-Protective Agents
000019623 650_7 $$0EC 1.11.1.5$$2NLM Chemicals$$aCytochrome-c Peroxidase
000019623 650_7 $$2WoSType$$aJ
000019623 7001_ $$0P:(DE-HGF)0$$aKapralov, A.A.$$b1
000019623 7001_ $$0P:(DE-HGF)0$$aYanamala, N.$$b2
000019623 7001_ $$0P:(DE-HGF)0$$aTyurina, Y.Y.$$b3
000019623 7001_ $$0P:(DE-HGF)0$$aAmoscato, A.A.$$b4
000019623 7001_ $$0P:(DE-HGF)0$$aPearce, L.$$b5
000019623 7001_ $$0P:(DE-HGF)0$$aPeterson, J.$$b6
000019623 7001_ $$0P:(DE-HGF)0$$aHuang, Z.$$b7
000019623 7001_ $$0P:(DE-HGF)0$$aJiang, J.$$b8
000019623 7001_ $$0P:(DE-HGF)0$$aSamhan-Arias, A.K.$$b9
000019623 7001_ $$0P:(DE-HGF)0$$aMaeda, A.$$b10
000019623 7001_ $$0P:(DE-HGF)0$$aFeng, W.$$b11
000019623 7001_ $$0P:(DE-HGF)0$$aWasserloos, K.$$b12
000019623 7001_ $$0P:(DE-HGF)0$$aBelikova, N.A.$$b13
000019623 7001_ $$0P:(DE-HGF)0$$aTyurin, V.A.$$b14
000019623 7001_ $$0P:(DE-HGF)0$$aWang, H.$$b15
000019623 7001_ $$0P:(DE-HGF)0$$aFletcher, J.$$b16
000019623 7001_ $$0P:(DE-HGF)0$$aWang, Y.$$b17
000019623 7001_ $$0P:(DE-HGF)0$$aVlasova, Il.$$b18
000019623 7001_ $$0P:(DE-Juel1)VDB44599$$aKlein-Seetharaman, J.$$b19$$uFZJ
000019623 7001_ $$0P:(DE-HGF)0$$aStoyanovsky, D.A.$$b20
000019623 7001_ $$0P:(DE-HGF)0$$aBayir, H.$$b21
000019623 7001_ $$0P:(DE-HGF)0$$aPitt, B.R.$$b22
000019623 7001_ $$0P:(DE-HGF)0$$aEpperly, M.W.$$b23
000019623 7001_ $$0P:(DE-HGF)0$$aGreenberger, J.S.$$b24
000019623 7001_ $$0P:(DE-HGF)0$$aKagan, V.E.$$b25
000019623 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/ncomms1499$$gVol. 2, p. 497$$p497$$q2<497$$tNature Communications$$v2$$x2041-1723$$y2011
000019623 8567_ $$uhttp://dx.doi.org/10.1038/ncomms1499
000019623 8564_ $$uhttps://juser.fz-juelich.de/record/19623/files/ncomms1499.pdf$$yOpenAccess
000019623 8564_ $$uhttps://juser.fz-juelich.de/record/19623/files/ncomms1499.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000019623 909CO $$ooai:juser.fz-juelich.de:19623$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000019623 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000019623 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR
000019623 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000019623 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000019623 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000019623 915__ $$0StatID:(DE-HGF)0040$$2StatID$$aPeer review unknown
000019623 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000019623 9141_ $$y2011
000019623 9131_ $$0G:(DE-Juel1)FUEK505$$aDE-HGF$$bSchlüsseltechnologien$$kP45$$lBiologische Informationsverarbeitung$$vBioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung$$x0
000019623 9132_ $$0G:(DE-HGF)POF3-551$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lBioSoft  Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vFunctional Macromolecules and Complexes$$x0
000019623 9201_ $$0I:(DE-Juel1)ICS-5-20110106$$gICS$$kICS-5$$lMolekulare Biophysik$$x0
000019623 970__ $$aVDB:(DE-Juel1)134493
000019623 9801_ $$aFullTexts
000019623 980__ $$aVDB
000019623 980__ $$aConvertedRecord
000019623 980__ $$ajournal
000019623 980__ $$aI:(DE-Juel1)ICS-5-20110106
000019623 980__ $$aUNRESTRICTED
000019623 981__ $$aI:(DE-Juel1)IBI-6-20200312
000019623 981__ $$aI:(DE-Juel1)ER-C-3-20170113