Home > Publications database > A mitochondrial-targeted inhibitor of cytochrorme c peroxidase mitigates radiation-induced death > print

001     19623
005     20240610120840.0
024 7 _ |2 pmid
|a pmid:21988913
024 7 _ |2 DOI
|a 10.1038/ncomms1499
024 7 _ |2 WOS
|a WOS:000296787300010
024 7 _ |2 altmetric
|a altmetric:404571
024 7 _ |2 Handle
|a 2128/24486
024 7 _ |2 ISSN
|a 2041-1723
037 _ _ |a PreJuSER-19623
041 _ _ |a eng
082 _ _ |a 500
084 _ _ |2 WoS
|a Multidisciplinary Sciences
100 1 _ |0 P:(DE-HGF)0
|a Atkinson, J.
|b 0
245 _ _ |a A mitochondrial-targeted inhibitor of cytochrorme c peroxidase mitigates radiation-induced death
260 _ _ |a London
|b Nature Publishing Group
|c 2011
300 _ _ |a 497
336 7 _ |0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
|a Journal Article
336 7 _ |2 DataCite
|a Output Types/Journal article
336 7 _ |0 0
|2 EndNote
|a Journal Article
336 7 _ |2 BibTeX
|a ARTICLE
336 7 _ |2 ORCID
|a JOURNAL_ARTICLE
336 7 _ |2 DRIVER
|a article
440 _ 0 |0 25143
|a Nature Communications
|v 2
520 _ _ |a The risk of radionuclide release in terrorist acts or exposure of healthy tissue during radiotherapy demand potent radioprotectants/radiomitigators. Ionizing radiation induces cell death by initiating the selective peroxidation of cardiolipin in mitochondria by the peroxidase activity of its complex with cytochrome c leading to release of haemoprotein into the cytosol and commitment to the apoptotic program. Here we design and synthesize mitochondria-targeted triphenylphosphonium-conjugated imidazole-substituted oleic and stearic acids that blocked peroxidase activity of cytochrome c/cardiolipin complex by specifically binding to its haem-iron. We show that both compounds inhibit pro-apoptotic oxidative events, suppress cyt c release, prevent cell death, and protect mice against lethal doses of irradiation. Significant radioprotective/radiomitigative effects of imidazole-substituted oleic acid are observed after pretreatment of mice from 1 h before through 24 h after the irradiation.
536 _ _ |0 G:(DE-Juel1)FUEK505
|2 G:(DE-HGF)
|a BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung
|c P45
|x 0
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Animals
650 _ 2 |2 MeSH
|a Cell Death: drug effects
650 _ 2 |2 MeSH
|a Cell Death: radiation effects
650 _ 2 |2 MeSH
|a Cytochrome-c Peroxidase: antagonists & inhibitors
650 _ 2 |2 MeSH
|a Electron Spin Resonance Spectroscopy
650 _ 2 |2 MeSH
|a Enzyme Inhibitors: chemistry
650 _ 2 |2 MeSH
|a Enzyme Inhibitors: pharmacology
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Mice
650 _ 2 |2 MeSH
|a Mice, Inbred C57BL
650 _ 2 |2 MeSH
|a Mitochondria: drug effects
650 _ 2 |2 MeSH
|a Mitochondria: enzymology
650 _ 2 |2 MeSH
|a Models, Molecular
650 _ 2 |2 MeSH
|a Molecular Dynamics Simulation
650 _ 2 |2 MeSH
|a Radiation-Protective Agents: chemistry
650 _ 2 |2 MeSH
|a Radiation-Protective Agents: pharmacology
650 _ 7 |0 0
|2 NLM Chemicals
|a Enzyme Inhibitors
650 _ 7 |0 0
|2 NLM Chemicals
|a Radiation-Protective Agents
650 _ 7 |0 EC 1.11.1.5
|2 NLM Chemicals
|a Cytochrome-c Peroxidase
650 _ 7 |2 WoSType
|a J
700 1 _ |0 P:(DE-HGF)0
|a Kapralov, A.A.
|b 1
700 1 _ |0 P:(DE-HGF)0
|a Yanamala, N.
|b 2
700 1 _ |0 P:(DE-HGF)0
|a Tyurina, Y.Y.
|b 3
700 1 _ |0 P:(DE-HGF)0
|a Amoscato, A.A.
|b 4
700 1 _ |0 P:(DE-HGF)0
|a Pearce, L.
|b 5
700 1 _ |0 P:(DE-HGF)0
|a Peterson, J.
|b 6
700 1 _ |0 P:(DE-HGF)0
|a Huang, Z.
|b 7
700 1 _ |0 P:(DE-HGF)0
|a Jiang, J.
|b 8
700 1 _ |0 P:(DE-HGF)0
|a Samhan-Arias, A.K.
|b 9
700 1 _ |0 P:(DE-HGF)0
|a Maeda, A.
|b 10
700 1 _ |0 P:(DE-HGF)0
|a Feng, W.
|b 11
700 1 _ |0 P:(DE-HGF)0
|a Wasserloos, K.
|b 12
700 1 _ |0 P:(DE-HGF)0
|a Belikova, N.A.
|b 13
700 1 _ |0 P:(DE-HGF)0
|a Tyurin, V.A.
|b 14
700 1 _ |0 P:(DE-HGF)0
|a Wang, H.
|b 15
700 1 _ |0 P:(DE-HGF)0
|a Fletcher, J.
|b 16
700 1 _ |0 P:(DE-HGF)0
|a Wang, Y.
|b 17
700 1 _ |0 P:(DE-HGF)0
|a Vlasova, Il.
|b 18
700 1 _ |0 P:(DE-Juel1)VDB44599
|a Klein-Seetharaman, J.
|b 19
|u FZJ
700 1 _ |0 P:(DE-HGF)0
|a Stoyanovsky, D.A.
|b 20
700 1 _ |0 P:(DE-HGF)0
|a Bayir, H.
|b 21
700 1 _ |0 P:(DE-HGF)0
|a Pitt, B.R.
|b 22
700 1 _ |0 P:(DE-HGF)0
|a Epperly, M.W.
|b 23
700 1 _ |0 P:(DE-HGF)0
|a Greenberger, J.S.
|b 24
700 1 _ |0 P:(DE-HGF)0
|a Kagan, V.E.
|b 25
773 _ _ |0 PERI:(DE-600)2553671-0
|a 10.1038/ncomms1499
|g Vol. 2, p. 497
|p 497
|q 2<497
|t Nature Communications
|v 2
|x 2041-1723
|y 2011
856 7 _ |u http://dx.doi.org/10.1038/ncomms1499
856 4 _ |u https://juser.fz-juelich.de/record/19623/files/ncomms1499.pdf
|y OpenAccess
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|y OpenAccess
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914 1 _ |y 2011
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