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@ARTICLE{Ggelein:19667,
      author       = {Gögelein, C. and Wagner, D. and Cardinaux, F. and Nägele,
                      G. and Egelhaaf, S.U.},
      title        = {{E}ffect of glycerol and dimethyl sulfoxide on the phase
                      behavior of lysozyme: {T}heory and experiments},
      journal      = {The journal of chemical physics},
      volume       = {136},
      issn         = {0021-9606},
      address      = {Melville, NY},
      publisher    = {American Institute of Physics},
      reportid     = {PreJuSER-19667},
      pages        = {015102},
      year         = {2012},
      note         = {We thank the International Helmholtz Research School of
                      Biophysics and Soft Matter (IHRS BioSoft) (IHRS BioSoft) and
                      the Deutsche Forschungsgemeinschaft (DFG) for financial
                      support.},
      abstract     = {Salt, glycerol, and dimethyl sulfoxide (DMSO) are used to
                      modify the properties of protein solutions. We
                      experimentally determined the effect of these additives on
                      the phase behavior of lysozyme solutions. Upon the addition
                      of glycerol and DMSO, the fluid-solid transition and the
                      gas-liquid coexistence curve (binodal) shift to lower
                      temperatures and the gap between them increases. The
                      experimentally observed trends are consistent with our
                      theoretical predictions based on the thermodynamic
                      perturbation theory and the Derjaguin-Landau-Verwey-Overbeek
                      model for the lysozyme-lysozyme pair interactions. The
                      values of the parameters describing the interactions, namely
                      the refractive indices, dielectric constants, Hamaker
                      constant and cut-off length, are extracted from literature
                      or are experimentally determined by independent experiments,
                      including static light scattering, to determine the second
                      virial coefficient. We observe that both, glycerol and DMSO,
                      render the potential more repulsive, while sodium chloride
                      reduces the repulsion.},
      keywords     = {Dimethyl Sulfoxide: chemistry / Glycerol: chemistry /
                      Muramidase: chemistry / Muramidase: metabolism / Protein
                      Binding / Quantum Theory / Sodium Chloride: chemistry /
                      Thermodynamics / Glycerol (NLM Chemicals) / Dimethyl
                      Sulfoxide (NLM Chemicals) / Sodium Chloride (NLM Chemicals)
                      / Muramidase (NLM Chemicals) / J (WoSType)},
      cin          = {ICS-3},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-3-20110106},
      pnm          = {BioSoft: Makromolekulare Systeme und biologische
                      Informationsverarbeitung},
      pid          = {G:(DE-Juel1)FUEK505},
      shelfmark    = {Physics, Atomic, Molecular $\&$ Chemical},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22239802},
      UT           = {WOS:000298967200040},
      doi          = {10.1063/1.3673442},
      url          = {https://juser.fz-juelich.de/record/19667},
}